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ACE I/D polymorphism in Alzheimer’s disease

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  • Published:
Central European Journal of Biology

Abstract

Angiotensin-converting enzyme (ACE) has been reported to show altered activity in patients with neurological diseases. The recent studies found that a 287 bp insertion/deletion (I/D) polymorphism of the ACE gene may be associated with susceptibility to Alzheimer’s disease (AD) but the results have been heterogenous between studies in Europe. In the present study we examined for the first time the association of ACE I/D polymorphism along with APOE genotype in 70 sporadic AD and 126 control subjects in Slovak Caucasians (Central Europe). An increased risk for AD was observed in subjects with at least one APOE*E4 allele (OR=3.99, 95% CI=1.97–8.08). No significant differences for the genotype distribution or the allele frequency were revealed comparing controls and patients for ACE gene. Gene-gene interaction analysis showed increase of the risk to develop AD in subjects carrying both the ACE DD genotype and the APOE*E4 allele (OR=10.32, 95% C.I. 2.67–39.81).

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Abbreviations

ACE:

Angiotensin-converting enzyme

AD:

Alzheimer’s disease

APOE:

Apolipoprotein E

CI:

Confidence interval

DMSO:

Dimethylsulfoxide

I/D:

Insertion/deletion

OR:

Odds ratio

PCR:

Polymerase chain reaction

RAS:

Renin — angiotensin systém

CNS:

central nervous system

CSF:

cebrospinal fluid

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Authors and Affiliations

  1. Department of Medical Biology, Faculty of Medicine, P.J.Safarik University, 04000, Kosice, Slovakia

    Marianna Trebunova, Eva Slaba, Viera Habalova & Zuzana Gdovinova

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  1. Marianna Trebunova
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  2. Eva Slaba
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  3. Viera Habalova
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  4. Zuzana Gdovinova
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Correspondence to Marianna Trebunova.

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Trebunova, M., Slaba, E., Habalova, V. et al. ACE I/D polymorphism in Alzheimer’s disease. cent.eur.j.biol. 3, 49–54 (2008). https://doi.org/10.2478/s11535-007-0051-9

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  • DOI: https://doi.org/10.2478/s11535-007-0051-9

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