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MCNP simulation of the dose distribution in liver cancer treatment for BNC therapy

  • Research Article
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Central European Journal of Physics

Abstract

The Boron Neutron Capture Therapy (BNCT) is based on selective uptake of boron in tumour tissue compared to the surrounding normal tissue. Infusion of compounds with boron is followed by irradiation with neutrons. Neutron capture on 10B, which gives rise to an alpha particle and recoiled 7Li ion, enables the therapeutic dose to be delivered to tumour tissue while healthy tissue can be spared. Here, therapeutic abilities of BNCT were studied for possible treatment of liver cancer using thermal and epithermal neutron beam. For neutron transport MCNP software was used and doses in organs of interest in ORNL phantom were evaluated. Phantom organs were filled with voxels in order to obtain depth-dose distributions in them. The result suggests that BNCT using an epithermal neutron beam could be applied for liver cancer treatment.

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References

  1. D. L. Bleuel, W. T. Chu, R. J. Donahue, B. A. Ludewigta, J. Vujic, Med. Phys. 25, 1725 (1998)

    Article  Google Scholar 

  2. F. El Moussaoui, T. El Bardouni, M. Azahra, A. Kamili, H. Boukhal, Cancer/Radiotherapie 12, 360 (2008)

    Article  Google Scholar 

  3. A. Zonta et al., Appl. Radiat. Isot. 67, S67 (2009)

    Article  Google Scholar 

  4. G. Gambarini, G. G. Daquino, R. L. Moss, M. Carrara, V. A. Nievaart, E. Vanossi, Radiat. Prot. Dosim. 126, 604 (2007)

    Article  Google Scholar 

  5. T. Pinelli et al., Eighth International Symposium, 1998, Los Angeles, CA, USA (Kluwer Academic/Plenum Publishers, New York, 2001) 1427

    Google Scholar 

  6. A. Zonta et al., J. Phys.: Conference Series 41, 484 (2006)

    Article  ADS  Google Scholar 

  7. S. Bortolussi et al., Appl. Radiat. Isot. 69, 1924 (2011)

    Article  Google Scholar 

  8. L. Kankaanranta et al., Int. J. Radiation Oncol. Biol. Phys. 69, 475 (2007)

    Article  Google Scholar 

  9. I. Porras, Phys. Med. Biol. 57, L1 (2008)

    Article  ADS  Google Scholar 

  10. I. Porras, Appl. Radiat. Isot. 69, 1838 (2011)

    Article  Google Scholar 

  11. H. Horiguchi, T. Nakamura, H. Kumada, H. Yanagie, M. Suzuki, H. Sagawa, Appl. Radiat. Isot. 69, 1882 (2011)

    Article  Google Scholar 

  12. D. Krstic, V. M. Markovic, Z. Jovanovic, B. Milenkovic, D. Nikezic, J. Atanackovic, Radiat. Prot. Dosim. DOI:10.1093/rpd/nct365.

  13. K. F. Eckerman, M. Cristy, J. C. Ryman The ORNL Mathematical Phantom Series, Oak Ridge National Laboratory Report, (Oak Ridge, TN, USA, 1996) Updated 08 April (2009)

    Google Scholar 

  14. D. Krstic, D. Nikezic, Comp. Phys. Commun. 176, 33 (2007)

    Article  ADS  Google Scholar 

  15. X-5 Monte Carlo Team, MCNP’a General Monte Carlo N-Particle Transport Code, Version 5 Vol. I: Overview and Theory (Los Alamos National Laboratory, Los Alamos, 2003)

    Google Scholar 

  16. T. Matsumoto, Nucl. Instrum. Meth. A 580, 552 (2007)

    Article  ADS  Google Scholar 

Download references

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Authors and Affiliations

  1. Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

    Dragana Krstic, Zoran Jovanovic, Vladimir Markovic & Dragoslav Nikezic

  2. Faculty of Technical Science, University of Kragujevac, Svetog Save 65, 32000, Cacak, Serbia

    Vlade Urosevic

Authors
  1. Dragana Krstic
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  2. Zoran Jovanovic
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  3. Vladimir Markovic
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  4. Dragoslav Nikezic
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  5. Vlade Urosevic
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Correspondence to Dragana Krstic.

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Krstic, D., Jovanovic, Z., Markovic, V. et al. MCNP simulation of the dose distribution in liver cancer treatment for BNC therapy. centr.eur.j.phys. 12, 714–718 (2014). https://doi.org/10.2478/s11534-014-0507-2

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  • DOI: https://doi.org/10.2478/s11534-014-0507-2

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