Central European Journal of Chemistry

, Volume 12, Issue 7, pp 788–795 | Cite as

Azobenzene functionalized mesoporous AlMCM-41-type support for drug release applications

  • Raul-Augustin Mitran
  • Daniela Berger
  • Laura Băjenaru
  • Silviu Năstase
  • Cristian Andronescu
  • Cristian MateiEmail author
Research Article RICCCE 18


A light-responsive material, aminoazobenzene functionalized AlMCM-41, was synthesized and characterized in order to be used as carrier for drug delivery devices. The light-induced hydrophobic-hydrophilic switching effect of azobenzene functionalized aluminosilicate was exploited in the release of irinotecan, a cytostatic drug. To obtain the functionalized mesoporous support, an azobenzene-silane precursor was synthesized by coupling 4-(4′-aminophenylazo) benzoic acid with 3-aminopropyl triethoxysilane and further grafted on AlMCM-41. The azobenzene functionalized mesoporous aluminosilicate exhibited no significant toxicity towards murine fibroblast healthy cells and a reduced toxicity towards murine melanocyte cells. The hybrid materials obtained by loading irinotecan on AlMCM-41 (wt. 35.4%) and aminoazobenzene modified AlMCM-41 (wt. 22%), respectively were characterized by FTIR, small and wide angle XRD, N2 adsorption-desorption isotherms and DSC analyses. A two-fold increase in the drug release rate from azobenzene functionalized aluminosilicate in phosphate buffer solution under UV irradiation was noticed, as compared with dark conditions. Moreover, the azobenzene functionalization of AlMCM-41 significantly increased the irinotecan delivery rate and total cumulative release in comparison with the pristine AlMCM-41 in similar conditions.


Aluminosilicate Drug delivery systems Aminoazobenzene Light-responsive material Irinotecan 


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Copyright information

© Versita Warsaw and Springer-Verlag Wien 2014

Authors and Affiliations

  • Raul-Augustin Mitran
    • 1
    • 2
  • Daniela Berger
    • 1
  • Laura Băjenaru
    • 1
  • Silviu Năstase
    • 1
  • Cristian Andronescu
    • 3
  • Cristian Matei
    • 1
    Email author
  1. 1.Faculty of Applied Chemistry and Materials ScienceUniversity “Politehnica” of BucharestBucharestRomania
  2. 2.SARA Pharm SolutionsBucharestRomania
  3. 3.“Ilie Murgulescu” Institute of Physical ChemistryRomanian Academy of SciencesBucharestRomania

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