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Synthesis of poly(vinyl alcohol) — hydroxyapatite composites and characterization of their bioactivity

  • Review Article
  • Published:
Central European Journal of Chemistry

Abstract

A series of poly(vinyl alcohol) membranes reinforced with hydroxyapatite in various weight percent — 0%, 10%, 20%, 30%, 40% and 50% were prepared. Hydroxyapatite was prepared by a sol-gel procedure using diammonium hydrogen phosphate and calcium nitrate tetrahydrate as starting materials in an alkaline aqueous environment and then mixed with a solution of poly(vinyl alcohol), which was prepared by dissolving it in water at 85°C.

The different mixtures were cast in a mould and evaporated for 7 days at a temperature of 30°C to obtain 1 mm thin membranes. FTIR spectroscopy was used to identify the different functional groups in the composites. The surface morphology was examined using a scanning electron microscope. In vitro bioactivity tests in Simulated Blood Fluid were performed for up to 28 days, especially for the membrane containing 50 wt.% HA. SEM was used to characterise the surface microstructure of biocomposite membranes before and after soaking in SBF. It was observed that the formation of clusters in membranes increases with increasing amount of HA. The clusters are formed due to agglomeration and crystal growth of HA particles during drying of the membranes. The in vitro bioactivity was found to increase with soaking time of biocomposite materials in simulated blood fluid.

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Authors and Affiliations

  1. Faculty of Chemistry, Brno University of Technology, Brno, 612 00, Czech Republic

    Zuzana Balgová, Martin Palou & Jaromír Wasserbauer

  2. Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, 812 37, Bratislava, Slovakia

    Martin Palou & Jana Kozánková

Authors
  1. Zuzana Balgová
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  2. Martin Palou
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  3. Jaromír Wasserbauer
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  4. Jana Kozánková
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Correspondence to Zuzana Balgová.

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Balgová, Z., Palou, M., Wasserbauer, J. et al. Synthesis of poly(vinyl alcohol) — hydroxyapatite composites and characterization of their bioactivity. cent.eur.j.chem. 11, 1403–1411 (2013). https://doi.org/10.2478/s11532-013-0283-7

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  • DOI: https://doi.org/10.2478/s11532-013-0283-7

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