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The first synthesis of 3-deoxyoripavine and its utilization in the preparation of 10-deoxyaporphines and cyprodime

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Central European Journal of Chemistry

Abstract

The synthesis of 3-deoxyoripavine (7) was realized as a novel and promising intermediate towards the synthesis of the important class of dopaminergic and/or serotonergic 10-deoxyaporphines and the special pharmacological tool µ opioid antagonist cyprodime. Generally, the preparation of these valuable biologically active compounds was achieved in remarkable yields.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Medical and Health Science Centre, University of Debrecen, H-4010, Debrecen, Hungary

    Attila Sipos & Attila C. Bényei

  2. Department of Physical Chemistry, University of Debrecen, H-4010, Debrecen, Hungary

    Antal Udvardy & Attila C. Bényei

  3. Department of Organic Chemistry, University of Debrecen, H-4010, Debrecen, Hungary

    Sándor Berényi

Authors
  1. Attila Sipos
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  2. Antal Udvardy
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  3. Attila C. Bényei
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  4. Sándor Berényi
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Correspondence to Attila Sipos.

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This paper is dedicated to the memory of Prof. Sándor Makleit who passed away on 27.09.2012

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Sipos, A., Udvardy, A., Bényei, A.C. et al. The first synthesis of 3-deoxyoripavine and its utilization in the preparation of 10-deoxyaporphines and cyprodime. cent.eur.j.chem. 11, 1278–1285 (2013). https://doi.org/10.2478/s11532-013-0256-x

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  • DOI: https://doi.org/10.2478/s11532-013-0256-x

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