Skip to main content
SpringerLink
Log in

Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

  • Research Article
  • Published:
Central European Journal of Chemistry

Abstract

New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. X. Zhang, S.J. Lippard, Curr. Opin. Chem. Biol. 7, 481 (2003)

    Article  CAS  Google Scholar 

  2. P. P. Silva, I.M. Marzano, M.I.P.S.E. Pereira-Maia, Global J. Inorg. Chem. 21, 252 (2011)

    Google Scholar 

  3. M. J. Clarke, Coord. Chem. Rev. 232, 69 (2002)

    Article  CAS  Google Scholar 

  4. B. Singh, R. Srivastava, K.K. Narang, Synth. React. Inorg Met.-Org. Chem. 30, 1175 (2000)

    Article  CAS  Google Scholar 

  5. J. Cymerman-Craig, D. Willis, S.P. Rubbo, S. Edgar, Nature 176, 34 (1955)

    Article  CAS  Google Scholar 

  6. R. Malhorta, S. Kumar, K.S. Dhidsa, Indian J. Chem. 32A, 5457 (1993)

    Google Scholar 

  7. Z. Muhi-Eldeen, K. Al-Obidi, M. Nadir, F. Rochev, Eur. J. Med. Chem. 27, 101 (1992)

    Article  CAS  Google Scholar 

  8. J. Martinez, A. Martinez, M.L. Cuenca, A.D. Lopez, Synth. React. Inorg. Met.-Org. Chem. 18, 881 (1988)

    Article  CAS  Google Scholar 

  9. M. G. Ebd ElWahed, A.M. Hassan, H.A. Hammad, M.M. El Desoky, Bull. Korean. Chem. Soc. 13, 113 (1992)

    Google Scholar 

  10. V. Mahalingam, N. Chitrapriya, M. Zeller, K. Natarajan, Polyhedron, 28, 1532 (2009)

    Article  CAS  Google Scholar 

  11. A. P.S. Fontes, W. Guerra, F.C. Machado, M.V. de Almeida, W.A. Alves, A.M.D.C. Ferreira, A. Paduan-Filho, Trans. Metal Chem. 29, 382 (2004)

    CAS  Google Scholar 

  12. N. Dodoff, K. Grancharov, N. Spassovska, J. Inorg. Biochem. 60, 257 (1995)

    Article  CAS  Google Scholar 

  13. K. K. Narang, V.P. Singh, Synth. React. Inorg. Met. — Org. Chem. 23, 971 (1993)

    Article  CAS  Google Scholar 

  14. P. Sur, S.P. Chatterjee, P. Roy, B. Sur, Cancer Letters 94, 27 (1995)

    Article  CAS  Google Scholar 

  15. W. Geary, J. Coord. Chem. Rev. 7, 81 (1971)

    Article  CAS  Google Scholar 

  16. K. Nakamoto, Infrared, Raman Spectra of Inorganic and Coordination Compounds, 5th edition (Wiley, New York, 1997)

    Google Scholar 

  17. N. T. Abdel Ghani, A.M. Mansour, J. Mol. Structure, 991, 108 (2011)

    Article  CAS  Google Scholar 

  18. W. Guerra, M. V. de Almeida, H. Silva, A. P. S. Fontes, Quím. Nova, 28, 809 (2005)

    Article  CAS  Google Scholar 

  19. D. Kushev, R. Grunert, N. Spassovska, E. Golovinsky, P.J. Bednarski, J. Inorg. Biochem. 96, 469 (2003)

    Article  CAS  Google Scholar 

  20. P. Drozdzewski, A. Brozyna, M. Kubiak, T. Lis, Vibrational Spectroscopy, 40, 118 (2006)

    Article  CAS  Google Scholar 

  21. W. Guerra, H. Silva, M.V. de Almeida, A.P.S. Fontes, Quím. Nova, 30, 56 (2007)

    Article  CAS  Google Scholar 

  22. F. K. Keter, S. Kanyanda, S.L. Lyantagaye, J. Darkwa, D.J.P. Rees, M. Meyer, Cancer Chemother. Pharmacol. 63, 127 (2008)

    Article  CAS  Google Scholar 

  23. B. Lippert, Cisplatin: Chemistry and Biochemistry of Leading Anticancer Drugs (Wiley-VCH, Germany 1999)

    Book  Google Scholar 

  24. G. D. Souza, L.E. Fernandes, M.A. Rodrigues, P.P. Silva, E.C. Pereira-Maia, W. Guerra, Lat. Am. J. Pharm. 31, 620 (2012)

    Google Scholar 

  25. S. Gómez-Ruiz, B. Gallego, Z. Zizak, E. Hey-Hawkins, Z.D. Juranic, G.N. Kaluderovic, Polyhedron 29, 354 (2010)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil

    Gustavo D. de Souza, Mônica A. Rodrigues, Lucianno E. Fernandes, Reinaldo Ruggiero & Wendell Guerra

  2. Chemistry Department, Federal University of Minas Gerais, Campus Pampulha, 31, 270-901, Belo Horizonte — MG, Brazil

    Priscila P. Silva & Elene C. Pereira-Maia

Authors
  1. Gustavo D. de Souza
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mônica A. Rodrigues
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lucianno E. Fernandes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Priscila P. Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Reinaldo Ruggiero
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Elene C. Pereira-Maia
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Wendell Guerra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wendell Guerra.

About this article

Cite this article

de Souza, G.D., Rodrigues, M.A., Fernandes, L.E. et al. Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity. cent.eur.j.chem. 11, 290–294 (2013). https://doi.org/10.2478/s11532-012-0156-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11532-012-0156-5

Keywords

Search

Navigation