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Enantioselective inhibition of immobilized acetylcholinesterase in biosensor determination of pesticides

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Central European Journal of Chemistry

Abstract

Chiral effects for the inhibition of acetylcholinesterase by organophosphorus pesticides were investigated for insecticide malathion and malaoxon, which is a metabolic product of malathion in living organisms. Studies were carried out using a bienzymatic biosensor with immobilized acetylcholinesterase, choline oxidase, and with Prussian Blue used as a mediator. In both cases the R enantiomers accelerate acetylocholinesterase inhibition. The chiral effect in inhibition was much more pronounced in fast flow measurements than in batch measurements.

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Correspondence to Marzena Kaniewska.

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Kaniewska, M., Jońca, J., Połeć, I. et al. Enantioselective inhibition of immobilized acetylcholinesterase in biosensor determination of pesticides. cent.eur.j.chem. 10, 1760–1765 (2012). https://doi.org/10.2478/s11532-012-0101-7

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  • DOI: https://doi.org/10.2478/s11532-012-0101-7

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