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Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles

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Central European Journal of Chemistry

Abstract

A new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial drugs against most of employed strains, as evident from the screening data.

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Authors and Affiliations

  1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India

    Chetan B. Sangani, Divyesh C. Mungra, Manish P. Patel & Ranjan G. Patel

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  1. Chetan B. Sangani
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  2. Divyesh C. Mungra
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  3. Manish P. Patel
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  4. Ranjan G. Patel
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Correspondence to Ranjan G. Patel.

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Sangani, C.B., Mungra, D.C., Patel, M.P. et al. Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles. cent.eur.j.chem. 9, 635–647 (2011). https://doi.org/10.2478/s11532-011-0041-7

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  • DOI: https://doi.org/10.2478/s11532-011-0041-7

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