Skip to main content
Log in

New approaches in layer by layer synthesis of collagen/hydroxyapatite composite materials

  • Research Article
  • Published:
Central European Journal of Chemistry

Abstract

The aim of this work was to increase our understanding of collagen (COLL)/ hydroxyapatite (HA) composite materials; more specifically, we focused on the study of the influence of the precursorconcentrations over the final content of deposited HA. We found that the increase of the precursor concentrations led to better mineralization (on the basis of the content of deposited mineral phase). Regardless of the precursor concentrations, the content of the deposited amount was found to increase with the increase of the number of deposited layers. Quantification of the mineral phase amount was achieved by gravimetric determination. Based on the determined deposition equation the number of layers can be easily determined in order to obtain composite materials with desired content of mineral phase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. S. Bandyopadhyay-Ghosh, Trends Biomater. Artif. Organs 22, 112 (2008)

    Google Scholar 

  2. J. Venugopal, S. Ramakrishna, 2007 International Forum on Biomedical Textile Materials, 30 May–2 June 2007, Shanghai, China (College of Textiles, Shanghai, 2007) 121

    Google Scholar 

  3. S.M. Barinov, Russian Chemical Reviews 79, 13 (2010)

    Article  CAS  Google Scholar 

  4. T. Matsuno, T. Nakamura, K.I. Kuremoto, S. Notazawa, T. Nakahara, Y. Hashimoto, et al., Dental Materials Journal 25, 138 (2006)

    Article  CAS  Google Scholar 

  5. M. Spector, Clin. Plast. Surg. 21, 437 (1994)

    CAS  Google Scholar 

  6. C.E. Rawlings, Neurosurgery 33, 935 (1993)

    Article  Google Scholar 

  7. J.P. Schmitz, J.O. Hollinger, S.B. Milam, J. Oral Maxillofac Surg. 57, 1122 (1999)

    Article  CAS  Google Scholar 

  8. S.V. Dorozhkin, Biomaterials 31, 1465 (2010)

    Article  CAS  Google Scholar 

  9. S.V. Dorozhkin, Acta Biomaterialia 6, 715 (2010)

    Article  CAS  Google Scholar 

  10. S.V. Dorozhkin, Journal of Materials Science 44, 2343 (2009)

    Article  CAS  Google Scholar 

  11. R. Maine, R.E. Burgeson (Eds.), Structure and Function of Collagen Types (Acad. Press, Orlando, 1978)

    Google Scholar 

  12. V. Trandafir, G. Popescu, M.G. Albu, H. Iovu, M. Georgescu, Bioproduse pe baza de colagen (Ars Docendi, Bucuresti, 2007) 334 (In Romanian)

    Google Scholar 

  13. F.-Z. Cui, Y. Li, J. Ge, Materials Science and Engineering R 57, 1 (2007)

    Article  Google Scholar 

  14. H. Ehrlich, International Geology Review 52, 661 (2010)

    Article  Google Scholar 

  15. S.H. Teng, E.J. Lee, P. Wang, D.S. Shin, H.E. Kim, Journal of Biomedical Materials Research, Part B-Applied Biomaterials 87B, 132 (2008)

    Article  CAS  Google Scholar 

  16. S. Liao et al., Biomaterials 26, 7564 (2005)

    Article  CAS  Google Scholar 

  17. A. Ficai, E. Andronescu, G. Voicu, D. Manzu, M. Ficai, Materials Science & Engineering C-Materials for Biological Applications 29, 2217 (2009)

    CAS  Google Scholar 

  18. S. Lupu, A. Ficai, Revue Roumaine de Chimie 52, 1137 (2007)

    CAS  Google Scholar 

  19. M.C. Chang, J. Tanaka, Biomaterials 23, 4811 (2002)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Denisa Ficai.

About this article

Cite this article

Ilie, A., Andronescu, E., Ficai, D. et al. New approaches in layer by layer synthesis of collagen/hydroxyapatite composite materials. cent.eur.j.chem. 9, 283–289 (2011). https://doi.org/10.2478/s11532-011-0002-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11532-011-0002-1

Keywords

Navigation