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Stability-indicating derivative spectrophotometry method for the determination of biapenem in the presence of its degradation products

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Central European Journal of Chemistry

Abstract

A first-derivative UV spectrophotometric method, with or without the subtraction technique, was developed for the determination of biapenem in pharmaceutical dosage form in the presence of its degradation products. The method was based on the measurement of first-derivative amplitudes at zero crossing point (λ = 312 nm) and the peak-to-zero technique and validated with regard to linearity, limits of detection and quantitation, selectivity and precision. The observed rate constants for the degradation of biapenem were comparable to those obtained in the stability-indicating HPLC method.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-780, Poznań, Poland

    Judyta Cielecka-Piontek & Anna Jelińska

  2. Tanaka Laboratory in Hokkaido University, W7, Kita-ku, Sapporo, 060-8638, Japan

    Aran Lunzer

Authors
  1. Judyta Cielecka-Piontek
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  2. Aran Lunzer
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  3. Anna Jelińska
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Correspondence to Judyta Cielecka-Piontek.

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Cielecka-Piontek, J., Lunzer, A. & Jelińska, A. Stability-indicating derivative spectrophotometry method for the determination of biapenem in the presence of its degradation products. cent.eur.j.chem. 9, 35–40 (2011). https://doi.org/10.2478/s11532-010-0125-9

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  • DOI: https://doi.org/10.2478/s11532-010-0125-9

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