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Consequence of hydrogen atom abstraction from 5’-hydroxyl group of 2’-deoxyadenosine. Theoretical quantum mechanics study

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Central European Journal of Chemistry

Abstract

Reactive oxygen species (ROS) may generate different nucleoside/nucleotide radicals in a cell environment. In this study, the possibility of cyclic-2’-deoxyadenosines formation by a rearrangement of their free radicals was investigated. It seems that for cyclic-nucleosides formation, adoption of an O4’-exo conformation by the sugar moiety is necessary. However, this is the energetically unfavoured form of the 2-deoxyribose ring. Moreover, the creation of a O5’, C8 bond in purine deoxy-nucleosides/nucleotides leads to the termination of the DNA elongation process.

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Authors and Affiliations

  1. Department of Biopharmacy, Medical University of Lodz, 90-151, Lodz, Poland

    Bolesław T. Karwowski

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  1. Bolesław T. Karwowski
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Correspondence to Bolesław T. Karwowski.

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Karwowski, B.T. Consequence of hydrogen atom abstraction from 5’-hydroxyl group of 2’-deoxyadenosine. Theoretical quantum mechanics study. cent.eur.j.chem. 6, 450–455 (2008). https://doi.org/10.2478/s11532-008-0038-z

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  • DOI: https://doi.org/10.2478/s11532-008-0038-z

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