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Heteroareno-annelated estranes by triene cyclization

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Central European Journal of Chemistry

Abstract

17-Thienyl-and 17-benzo[b]thienyl-3-hydroxyestra-1,3,5(10),16-tetraenes were synthesized by either sequential or one-pot Suzuki cross-coupling and Wittig olefination reactions. At 160 °C, heteroaryl substituted steroids were observed to undergo thermal intramolecular cyclization to produce E-ring heteroareno-annelated estranes.

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Authors and Affiliations

  1. Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga-shi, 816-8580, Japan

    Masataka Watanabe

  2. Institute of Materials Chemistry and Engineering, Kyushu University, Kasuga-shi, 816-8580, Japan

    Taisuke Matsumoto, Shuntaro Mataka & Thies Thiemann

Authors
  1. Masataka Watanabe
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  2. Taisuke Matsumoto
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  3. Shuntaro Mataka
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  4. Thies Thiemann
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Watanabe, M., Matsumoto, T., Mataka, S. et al. Heteroareno-annelated estranes by triene cyclization. cent.eur.j.chem. 4, 375–402 (2006). https://doi.org/10.2478/s11532-006-0016-2

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  • DOI: https://doi.org/10.2478/s11532-006-0016-2

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