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Pyrazoles as molecular probes to study the properties of co-crystals by solid state NMR spectroscopy

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Central European Journal of Chemistry

Abstract

Equimolar mixtures of 3,5-dimethylpyrazole (1) with four NH-imidazoles (2–5) have been studied by13C and 15N CPMAS NMR and by DSC. In three cases, the solid mixture behaves as the sum of the individual components [imidazole (2), 2-methylimidazole (3) and 2,4(5)-dimethylimidazole (5)]. In one case [4,5-dimethylimidazole (4)], the mixture corresponds to a new species in which the dynamic behavior of1 no longer exists.

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Authors and Affiliations

  1. Departmento de Química Orgánica y Biología, Facultad de Ciencias, UNED, Senda del Rey 9, E-28040, Madrid, Spain

    Concepción López, Rosa M. Claramunt & M. Ángeles García

  2. Instituto de Química Médica, CSIC, Juan de la Cierva 3, E-28006, Madrid, Spain

    José Elguero

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  1. Concepción López
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  2. Rosa M. Claramunt
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  3. M. Ángeles García
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  4. José Elguero
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López, C., Claramunt, R.M., García, M.Á. et al. Pyrazoles as molecular probes to study the properties of co-crystals by solid state NMR spectroscopy. cent.eur.j.chem. 2, 660–671 (2004). https://doi.org/10.2478/BF02482729

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  • DOI: https://doi.org/10.2478/BF02482729

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