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Biologia

, Volume 73, Issue 6, pp 629–635 | Cite as

Orofacial clefts and infections during pregnancy

  • Agáta Molnárová
  • Drahomír Palenčár
  • Dagmar Fekiačová
  • Eva Bieliková
  • Eva Tichá
  • Eduard Ujházy
Original Article
  • 15 Downloads

Abstract

Orofacial clefts (OFCs) are common congenital malformations of the lip, palate, or both caused by complex genetic and environmental factors. Specific antibodies against viruses influenza, rubella, cytomegalovirus, Epstein-Barr, parotitis and hepatitis B were investigated serologically in children with orofacial clefts and in their mothers. The results were compared with those obtained in control children and their mothers. Evaluation of the results and their statistical processing supports the assumption that infection during pregnancy may have occurred in the series studied induced by viruses of influenza, rubella, cytomegalovirus and possibly also by the Epstein-Barr virus. No association with the viruses of hepatitis B and parotitis was established.

Keywords

Infections during pregnancy Orofacial clefts Cleft of the lip Cleft of the palate Cleft of the lip and palate 

Abbreviations

HIT

Hemagglutination inhibition test

KFR

Complement fixation test

NIR

Indirect immunofluorescence assay

ELISA

Enzyme-linked immunosorbent assay

RIA

Radioimmuno assay.4

Notes

Acknowledgments

This work was supported by the and Grant VEGA 2/0129/15. Authors would like to thank to team of Center for Orofacial Clefts in Hospital Ružinov Bratislava.

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Copyright information

© Institute of Molecular Biology, Slovak Academy of Sciences 2018

Authors and Affiliations

  • Agáta Molnárová
    • 1
  • Drahomír Palenčár
    • 1
  • Dagmar Fekiačová
    • 1
  • Eva Bieliková
    • 2
  • Eva Tichá
    • 3
  • Eduard Ujházy
    • 4
  1. 1.Department of Plastic Surgery, Faculty of MedicineComenius UniversityBratislavaSlovakia
  2. 2.Department of Gynecology, Faculty of MedicineComenius UniversityBratislavaSlovakia
  3. 3.Public Health Authority of the Slovak RepublicBratislavaSlovakia
  4. 4.Institute of Experimental Pharmacology and ToxicologyCentre of Experimental Medicine of the Slovak Academy of SciencesBratislavaSlovakia

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