Acta Parasitologica

, Volume 57, Issue 3, pp 228–234 | Cite as

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

  • Bijan Esmaeilnejad
  • Mousa Tavassoli
  • Siamak Asri-Rezaei
  • Bahram Dalir-Naghadeh
  • Hassan Malekinejad
Original Paper

Abstract

This study aimed to assess lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis. Red blood cell count (RBC), hemoglobin (Hb) concentration, packed cell volume (PCV), malondialdehyde (MDA) concentration, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activities and total antioxidant capacity (TAC) were determined in 15 goats naturally infected with B. ovis as well as same number of healthy goats. The parasitological diagnosis was confirmed using polymerase chain reaction (PCR) analysis by amplifying a partial 18S rRNA gene sequence of B. ovis. Percentage of parasitemia varied from 0.01 to 1%. The activities of erythrocyte GSH-Px, SOD, CAT and TAC were significantly lower (p<0.05) in the infected goats than in healthy ones. MDA concentration in erythrocytes of infected goats was significantly higher in infected goats than in healthy ones (pš0.05). Severity of parasitemia showed a positive correlation with the MDA and negative correlation with PCV, SOD, CAT, GSH-Px and TAC. Also, MDA was negatively correlated with PCV, SOD, CAT, GSH-Px and TAC. The results of this study suggested that oxidative damage to RBCs may contribute to the pathogenesis of anemia in caprine babesiosis.

Keywords

Babesia ovis goats oxidative stress antioxidants anemia 

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Copyright information

© Versita Warsaw and Springer-Verlag Wien 2012

Authors and Affiliations

  • Bijan Esmaeilnejad
    • 1
  • Mousa Tavassoli
    • 1
  • Siamak Asri-Rezaei
    • 2
  • Bahram Dalir-Naghadeh
    • 2
  • Hassan Malekinejad
    • 3
  1. 1.Department of Pathobiology, Faculty of Veterinary MedicineUrmia UniversityUrmiaIran
  2. 2.Departments of Clinical Sciences, Faculty of Veterinary MedicineUrmia UniversityUrmiaIran
  3. 3.Department of Basic SciencesFaculty of Veterinary MedicineUrmiaIran

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