Acta Parasitologica

, Volume 53, Issue 1, pp 110–114 | Cite as

Isolation of the cDNAs encoding secreted and membrane binding proteins from egg of Schistosoma japonicum (Chinese strain)

  • Chuanxin Yu
  • Fengxue Zhang
  • Xuren Yin
  • Mihoko Kikuchi
  • Kenji Hirayama
Research Note

Abstract

The granulomatous reaction which occurs around egg trapped in the intrahepatic venules ultimately may lead to fibrosis, which is the main pathogenesis of schistosomiasis. The excreted proteins from eggs play an important role during this process, and they may be a target for developing new strategies to control the hepatic pathogenesis caused by schistosome infection. In this study, fifteen genes encoding secreted or membrane binding protein were identified with the signal sequence trapping method by retrovirus mediated expression screening (SST-REX) of cDNAs from the egg of Schistosoma japonicum (Chinese strain).

Keywords

Schistosoma japonicum secretory or membrane binding protein signal sequence trapping (SST) 

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Copyright information

© Versita 2008

Authors and Affiliations

  • Chuanxin Yu
    • 1
  • Fengxue Zhang
    • 1
  • Xuren Yin
    • 1
  • Mihoko Kikuchi
    • 2
  • Kenji Hirayama
    • 2
  1. 1.Laboratory on Technology for Parasitic Diseases Prevention and Control, Ministry of HealthJiangsu Institute of Parasitic DiseasesWuxiChina
  2. 2.Department of Molecular Immunogenetics, Institute of Tropical MedicineNagasaki UniversityNagasakiJapan

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