Central European Journal of Medicine

, Volume 8, Issue 6, pp 799–802 | Cite as

Systemic lupus erythematosus followed by myasthenia gravis: a rare association

  • Elena Sîrbu
  • Oana MilaşEmail author
  • Maxim Petrica
  • Ligia Petrica
Case Report


Systemic lupus erythematosus (SLE) and myasthenia gravis (MG) are autoimmune diseases, their association in the same patient being rarely described. Here, we report a case of SLE in a 19-year-old girl who within 2 years of the diagnosis of SLE developed MG, and underwent thymectomy for a benign thymoma immediately thereafter.


Systemic lupus erythematosus Myasthenia gravis Thymectomy 


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  1. [1]
    Schofield RH. Autoimmune thyroid disease in systemic lupus erythematosus and Sjogren’s syndrome. Clin Exp Rheumatol 1996; 14:321–330Google Scholar
  2. [2]
    Moutsopoulos HM, Klippel JH, Pavlidis, Wolf RO, Sweet JB, Steinberg AD et al. Correlative histologic and serologic findings of sicca syndrome in patients with systemic lupus erythematosus. Arthritis Rheum 1980; 23:36–40PubMedCrossRefGoogle Scholar
  3. [3]
    Karpatkin S. Autoimmune thrombocytopaenicpurpura. Semin Haematol 1985;22:260–288Google Scholar
  4. [4]
    McDonagh JE, Isenberg D.A. Development of additional autoimmune diseases in a population of patients with systemic lupus erythematosus. Annals of rheumatic diseases 2000; 59(3):230–232CrossRefGoogle Scholar
  5. [5]
    Castrejón I, Shum K, Tseng CE, Askanase A. Association between myasthaenia gravis and systemic lupus erythematosus: three case reports and review of the literature. Scandinavian Journal of Rheumatology 2011;40(6):486–490PubMedCrossRefGoogle Scholar
  6. [6]
    Studart SA, Rodrigues CL, Soares CB et al. Systemic Lupus Erythematosus with muscle weakness due to Myasthenia Gravis. Revista Brasileira de Reumatologia 2011; 51(3):289–294PubMedCrossRefGoogle Scholar
  7. [7]
    Hrycek A. A sequence of pathologic events in a patient after thymectomy for myasthenia gravis. Rheumatology International 2012;32(1):245–248PubMedCrossRefGoogle Scholar
  8. [8]
    Louzir B, Ben Abdelhafidh N, Bahri M, M’Sadek F, Ksontini I, Boussema E, Othmani S. Association of systemic lupus erythematosis and myasthenia gravis. A new case report. La Tunisie Medicale 2003; 81(12):963–966Google Scholar
  9. [9]
    Vaiopoulos G, Sfikakis PP, Kapsimali V, Bokil K, Panayiotidis P, Aessopos A, Tsokos GC, Kaklamanis P. The association of systemic lupus erythematosis and myasthenia gravis. Postgraduate Medicine Journal 1994; 70: 741–745CrossRefGoogle Scholar
  10. [10]
    Park MJ, Kim YA, Lee SS, Kim BC, Kim MK, Cho KH. Appearance of systemic lupus erythematosus in patients with myasthenia gravis following thymectomy: two case reports. Journal of Korean Medical Science 2004; 19(1): 134–136PubMedCrossRefGoogle Scholar
  11. [11]
    Omar HA, Alzahrani MA, Al Bshabshe AA et al. Systemic lupus erythematosus after thymectomy for myasthenia gravis: a case report and review of the literature. Clinical and Experimental Nephrology 2010; 14(3):272–276PubMedCrossRefGoogle Scholar
  12. [12]
    Casado E, Gratacós J, Tolosa C, Martinez JM, Ojanguren I, Ariza A et al. Antimalarial myopathy: an underdiagnosed complication?Prospective longitudinal study of 119 patients. Annals of Rheumatic Diseases 2006; 65(3):385–390CrossRefGoogle Scholar

Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Elena Sîrbu
    • 1
  • Oana Milaş
    • 2
    Email author
  • Maxim Petrica
    • 3
  • Ligia Petrica
    • 2
    • 4
  1. 1.West University of TimişoaraTimişoaraRomania
  2. 2.Department of NephrologyCounty Emergency HospitalTimisoaraRomania
  3. 3.County Emergency Hospital Department of NeurologyTimişoaraRomania
  4. 4.University of Medicine and Pharmacy “Victor Babes”TimisoaraRomania

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