Photodynamic therapy (PDT) for disinfection of oral wounds. In vitro study
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- Matějka, Z., Adámková, V., Šmucler, R. et al. cent.eur.j.med (2012) 7: 118. doi:10.2478/s11536-011-0107-0
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The aim of this in vitro study was to compare the antimicrobial effects of photodynamic antimicrobial chemotherapy (PACT), an ordinary antiseptic (chlorhexidini digluconas), and an antibiotic therapy (bacitracinum zincicum and neomycini sulfas) in vitro.
Photodynamic therapy (PDT) is an area of great interest for its potential use as an antimicrobial therapy. It is currently a popular topic in modern medical literature. PDT is, according to recent publications, advantageous over other types of therapies because it acts nonspecifically and it is impossible to develop resistance to the therapy.
Materials and Methods
We investigated the antibacterial effect of these three forms of antiseptics on the selection of G+, G-, aerobic, and anaerobic bacteria that exist in the oral cavity and are involved in the formation of periodontal diseases.
Results & Conclusion
We found that the PACT device did not have a sufficient antimicrobial effect in vitro. In contrast, the disinfection agents containing chlorhexidini digluconas were effective and may be a safe, non-specific alternative to antibiotic treatments. Promising results from some clinical studies can have different mechanism of action as disinfection.