Central European Journal of Medicine

, Volume 6, Issue 2, pp 205–212 | Cite as

State of HPV16 integration in Lithuanian women with cervical neoplasia

  • Agne SepetieneEmail author
  • Zivile Gudlevicienė
  • Zana Bumbuliene
  • Grazina Drasutiene
  • Janina Didziapetriene
Research Article


Cervical cancer morbidity and mortality in Lithuania is one of the biggest in the European Union. The main risk factor of cervical cancer is human papillomavirus (HPV). The deletion of the HPV E2 gene influences HPV DNA integration into the cell genome, as well as a rapid progression of cervical lesions. The purpose of this study is to determine HPV, its types, and HPV 16 integration in different grades of cervical intraepithelial neoplasias (CIN). 253 women with cytological lesions were involved in the study. After a histology, 31 women were diagnosed with CIN I, 35 with CIN II, and 51 with CIN III. The biggest prevalence of HPV infection was detected in women younger than 25 years old (69.7%) and in women with CIN II (90.9%). HPV 16 was detected in 67.8% of all cases, with the highest prevalence in CIN III (84.4%). A partial integration form was detected in 65.0% of HPV 16 infected women, a complete virus integration in 26.5%, and an episomal form in 8.4% of cases. Our study concludes that in all the cases confirmed using a histology, the partial virus integration form of CIN was identified the most. It was less frequently detected in CIN I cases (60.0%), but more frequently in CIN II and CIN III cases (72.8 and 69.3%, respectively).


HPV prevalence HPV 16 integration Cervical intraepithelial neoplasia 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Agne Sepetiene
    • 1
    • 4
    Email author
  • Zivile Gudlevicienė
    • 2
  • Zana Bumbuliene
    • 1
    • 4
  • Grazina Drasutiene
    • 1
  • Janina Didziapetriene
    • 2
    • 3
  1. 1.Faculty of Medicine, Clinic of Obstetrics and GynecologyVilnius UniversityVilniusLithuania
  2. 2.Institute of OncologyVilnius UniversityVilniusLithuania
  3. 3.Faculty of Medicine, Clinic of Internal Medicine, General Practice and OncologyVilnius UniversityVilniusLithuania
  4. 4.Vilnius University Hospital Santariskiu ClinicVilniusLithuania

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