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Central European Journal of Biology

, Volume 7, Issue 2, pp 327–333 | Cite as

Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dőrfler

  • Pavle Mašković
  • Jelena Dragišić Maksimović
  • Vuk Maksimović
  • Jelena Blagojević
  • Mladen Vujošević
  • Nedeljko T. Manojlović
  • Marija Radojković
  • Milica Cvijović
  • Slavica Solujić
Research Article
  • 173 Downloads

Abstract

The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H.sendtneri was exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of chemical constituents, genotoxic and antimicrobial activities of the endemic species, H. sendtneri.

Keywords

Antimicrobial activity Genotoxicity Halacsya sendtneri Phenolic compounds 

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Copyright information

© © Versita Warsaw and Springer-Verlag Wien 2012

Authors and Affiliations

  • Pavle Mašković
    • 1
  • Jelena Dragišić Maksimović
    • 2
  • Vuk Maksimović
    • 2
  • Jelena Blagojević
    • 3
  • Mladen Vujošević
    • 3
  • Nedeljko T. Manojlović
    • 4
  • Marija Radojković
    • 5
  • Milica Cvijović
    • 1
  • Slavica Solujić
    • 6
  1. 1.Faculty of AgronomyUniversity of KragujevacČačakSerbia
  2. 2.Department of Life Sciences, Institute for Multidisciplinary ResearchUniversity of BelgradeBelgradeSerbia
  3. 3.Department of Genetic ResearchUniversity of Belgrade, Institute of Biological ResearchBelgradeSerbia
  4. 4.Department of Pharmacy, Medical FacultyUniversity of KragujevacKragujevacSerbia
  5. 5.Department of Biotechnology and Pharmaceutical Engineering, Faculty of TechnologyUniversity of Novi SadNovi SadSerbia
  6. 6.Faculty of ScienceUniversity of KragujevacKragujevacSerbia

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