Abstract
A case of ductal carcinomain situ (DCIS) with microinvasion arising in a radial scar of the breast is presented. A 57-year-old woman visited our hospital with bloody discharge from her left nipple. There were no abnormal findings on cytology, carcinoembryonic antigen (CEA) level of nipple discharge was <500 ng/ml, and mammograms were normal. After 2 years of careful periodic follow-up, spiculation without a central core appeared on mammograms. The CEA level of the nipple discharge increased to 1000 ng/ml. Ductgraphy showed a connection between the duct with the discharge and the center of the spiculation. Since these findings suggested malignancy, she underwent segmentectomy of the breast, and pathological examination showed a radial scar and DCIS with microinvasion in the ducts within the radiating bands of fibrous tissues. We discuss the characteristics of a radial scar and its relationship to breast cancer based on our experience and a review of the literature.
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Abbreviations
- DCIS:
-
Ductal carcinomain situ
- CEA:
-
Carcinoembryonic antigen
References
Semb C: Fibroadenomatosis cystica mammae.Acta Cbir Scand 10 (suppl): 1–484, 1928.
Alvarado-Cabrero I, Tavassoli FA: Neoplastic and malignant lesions involving or arising in a radial scar: a clinicopathologic analysis of 17 cases.Breast J 6:96–102, 2000.
Markopoulos C, Kakisis J, Koufopoulos K, Alevras P, Gogas H, Tziortziotis D, Floros D: Radial scar of the breast.Eur J Gynaec Oncol 20:147–149, 1999.
Anderson TJ, Battersby S: Radial scars of benign and malignant breasts: comparative features and significance.J Pathol 147:23–32, 1985.
Linell F, Ljungberg O, Andersson I: Breast carcinoma: aspects of early stages, progression and related problems.Acta Pathol Microbiol Scand 272 (Suppl):1–233, 1980.
Frouge C, Tristant H, Guinebretiere JM, Meunier M, Contesso G, Paola RD, Blery M: Mammographic lesions suggestive of radial scars: microscopic findings in 40 cases.Radiology 195:623–625, 1995.
Jacobs TW, Byrne C, Colditz G, Connolly JL, Schnitt SJ: Radial scars in benign breast-biopsy specimens and the risk of breast cancer.N Engl J Med 340:430–436, 1999.
Mitnick JS, Vazquez MF, Harris MN, Roses DF: Differentiation of radial scar from scirrhous carcinoma of the breast: mammographic-pathologic correlation.Radiology 173:697–700, 1989.
Franquet T, De Miguel C, Cozcolluela R, Donzo L, Franquet T: Spiculated lesions of the breast: mammographic-pathologic correlation.Radiographics 13:841–852, 1993.
King TA, Scharfenberg JC, Smetherman DH, Farkas EA, Bolton JS, Fuhman GM: A better understanding of the term radial scar.Am J Surg 180:428–433, 2000.
Elson BC, Helvie MA, Frank TS, Wilson TE, Alder DD: Tubular carcinoma of the breast: mode of presentation, mammographic appearance, and frequency of nodal metastasis.AJR 161:1173–1176, 1993.
Adler DD, Helvie MA, Oberman HA, Ikeda DM, Bhan AO: Radial sclerosing lesion of the breast: mammographic features.Radiology 176:737–740, 1990.
Patel A, Steel Y, McKenzie J, Letcher M, Delia Rovere GQ, Morgan MW: Radial scars: a review of 30 cases.Eur J Surg Oncol 23:202–205, 1997.
Fisher ER, Palekar AS, Kotwal N, Lipana N: A nonencapsulated sclerosing lesion of the breast.Am J Clin Pathol 71:240–246, 1979.
Anderson JA, Gram JB: Radial scar in the female breast: A long term follow-up of 32 cases.Cancer 53:2557–2560, 1984.
Iqbal M, Shoker BS, Foster CS, Jarvis C, Sibson R, Davies MPA: Molecular and genetic abnormalities in radial scar.Hum Pathol 33:715–722, 2002.
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Okita, A., Ohsumi, S., Takashima, S. et al. Non-palpable ductal carcinomain situ (DCIS) with microinvasion arising in a radial scar presenting with spiculation alone on mammograms: A case report. Breast Cancer 13, 107–111 (2006). https://doi.org/10.2325/jbcs.13.107
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DOI: https://doi.org/10.2325/jbcs.13.107