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A case of occult contralateral breast cancer incidentally detected by contrast-enhanced mri; report of a case with review of literature

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Abstract

We encountered a case of occult contralateral breast cancer, previously undetected by conventional imaging such as mammography (MMG) and ultrasonography (US), but incidentally detected by contrastenhanced magnetic resonance imaging (CE-MRI). We present it here with a review of the literature. A 67-year-old Japanese woman was referred to our hospital in October 2000 because of a 1.5 cm right breast lump detected in a medical checkup. MMG, US and fine needle aspiration cytology revealed a cancerous lesion during the right breast. No mass lesion was palpable nor was any detected by MMG or US in the left breast. Bilateral breast CE-MRI was performed for more detailed evaluation. Consequently, an occult contralateral breast cancerous lesion was detected incidentally by CE-MRI, with the images showing rapid initial enhancement of time to signal intensity curves. Before surgery, bilateral breast lesions were diagnosed as invasive ductal carcinoma by open biopsy. She underwent bilateral breast conserving surgery with bilateral axillary lymph node dissection. The postoperative course was uneventful and no recurrence has been noted as of January 18th, 2004. CE-MRI of the contralateral breast should be of value as a routine screen in those patients with a known or suspected malignancy in one breast considering the limits of breast cancer detection by such conventional modalities as MMG and US.

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References

  1. Egan RL: Bilateral breast carcinomas: role of mammography.Cancer 38: 931–938, 1976.

    Article  PubMed  CAS  Google Scholar 

  2. Orel SG, Reynolds C, Schnall MD, Solin LJ, Fraker DL, Sullivan DC: Breast carcinoma: MR imaging before reexcisional biopsy.Radiology 205: 429–436, 1997.

    PubMed  CAS  Google Scholar 

  3. Orel SG: High-resolution MR imaging for the detection, diagnosis, and staging of breast cancer.Radiographics 18: 903–912, 1998.

    PubMed  CAS  Google Scholar 

  4. Stack JP, Redmond OM, Codd MB, Dervan PA, Ennis JT: Breast disease: tissue characterization with Gd-DTPA enhancement profiles.Radiology 174: 491–494, 1990.

    PubMed  CAS  Google Scholar 

  5. The Japanese Breast Cancer Society: general rules for clinical and pathological recording of breast cancer. The 14th Edition. Tokyo: Kanehara & Co., 2000. (In Japanese)

  6. Tamaki Y, Akashi-Tanaka S, Ishida T, Uematsu T, Sawai Y, Kusama M, Nakamura S, Hisamatsu K, Tanji Y, Sato Y, Matsuura N: 3D imaging of intraductal spread of breast cancer and its clinical application for navigation surgery.Breast Cancer 9: 289–295, 2002.

    Article  PubMed  Google Scholar 

  7. Nagashima T, Suzuki M, Yagata H, Hashimoto H, Shishikura T, Imanaka N, Ueda T, Miyazaki M: Dynamic-enhanced MRI predicts metastatic potential of invasive ductal breast cancer.Breast Cancer 9: 226–230, 2002.

    Article  PubMed  Google Scholar 

  8. Harms SE, Flamig DP, Hesley KL, Meiches MD, Jensen RA, Evans WP, Savino DA, Wells RV: MR imaging of the breast with rotating delivery of excitation off resonance: clinical experience with pathologic correlation.Radiology 187: 493–501, 1993.

    PubMed  CAS  Google Scholar 

  9. Orel SG: MR imaging of the breast.Radiol Clin North Am 38: 899–913, 2000.

    Article  PubMed  CAS  Google Scholar 

  10. Komatsu S, Lee CJ, Ichikawa D, Hamashima T, Morofuji N, Shirono K, Hosokawa Y, Okabe H, Kurioka H, Oka T: Predictive Value of the Time Intensity Curves on Dynamic Contrast-Enhanced MRI for Lymphatic Spreading in Breast Cancer.Surgery Today 2005 in press.

    Google Scholar 

  11. Kerlikowske K, Grady D, Barclay J, Sickles EA, Ernster V: Effect of age, breast density, and family history on the sensitivity of first screening mammography.JAMA 276: 33–38, 1996.

    Article  PubMed  CAS  Google Scholar 

  12. Hlawatsch A, Teifke A, Schmidt M, Thelen M: Preoperative assessment of breast cancer: sonography versus MR imaging.AJR Am J Roentgenol 179: 1493–1501, 2002.

    PubMed  Google Scholar 

  13. Komatsu S, Lee CJ, Hosokawa Y, Ichikawa D, Hamashima T, Shirono K, Okabe H, Kurioka H, Oka T: Comparison of intraductal spread on dynamic contrast-enhanced MRI with clinicopathologic features in breast cancer.Jpn J Clin Oncol 34: 515–518, 2004.

    Article  PubMed  Google Scholar 

  14. Slanetz PJ, Edmister WB, Yeh ED, Talele AC, Kopans DB: Occult contralateral breast carcinoma incidentally detected by breast magnetic resonance imaging.Breast J 8: 145–148, 2002.

    Article  PubMed  Google Scholar 

  15. Smith LF, Henry-Tillman R, Mancino AT, Johnson A, Price Jones M, Westbrook KC, Harms S, Klimberg VS: Magnetic resonance imaging-guided core needle biopsy and needle localized excision of occult breast lesions.Am J Surg 182: 414–418, 2001.

    Article  PubMed  CAS  Google Scholar 

  16. Bedrosian I, Schlencker J, Spitz FR, Orel SG, Fraker DL, Callans LS, Schnall M, Reynolds C, Czerniecki BJ: Magnetic resonance imaging-guided biopsy of mammographically and clinically occult breast lesions.Ann Surg Oncol 9: 457–461, 2002.

    Article  PubMed  Google Scholar 

  17. Smith LF, Henry-Tillman R, Harms S, Hronas T, Mancino AT, Westbrook KC, Korourian S, Jones MP, Klimberg VS: Hematoma-directed ultrasound-guided breast biopsy.Ann Surg 233: 669–675, 2001.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Surgery, Kyoto First Red Cross Hospital, Japan

    Shuhei Komatsu, Chol Joo Lee, Takashi Hamashima, Koichi Shirono, Daisuke Ichikawa, Hideaki Kurioka & Takahiro Oka

  2. Departments of Anatomical Pathology and Laboratory Medicine, Kyoto First Red Cross Hospital, Japan

    Yohei Hosokawa

  3. Departments of Radiology, Kyoto First Red Cross Hospital, Japan

    Harumi Okabe

  4. Department of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramachi-hirokoji, 602-8566, Kamigyo-ku, Kyoto, Japan

    Shuhei Komatsu, Daisuke Ichikawa & Hisakazu Yamagishi

Authors
  1. Shuhei Komatsu
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  2. Chol Joo Lee
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  3. Yohei Hosokawa
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  4. Takashi Hamashima
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  5. Koichi Shirono
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  6. Daisuke Ichikawa
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  7. Harumi Okabe
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  8. Hideaki Kurioka
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  9. Hisakazu Yamagishi
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  10. Takahiro Oka
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Correspondence to Shuhei Komatsu.

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Komatsu, S., Lee, C.J., Hosokawa, Y. et al. A case of occult contralateral breast cancer incidentally detected by contrast-enhanced mri; report of a case with review of literature. Breast Cancer 12, 341–345 (2005). https://doi.org/10.2325/jbcs.12.341

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  • DOI: https://doi.org/10.2325/jbcs.12.341

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