Abstract
We report a case of phyllodes tumor (PT) with multiple lesions partly mimicking fibroadenoma (FA). A 43-year-old woman was referred to our institute because of a left breast mass which was diagnosed as FA clinically. During the follow-up, the mass gradually enlarged and excisional biopsy was performed to rule out malignant lesion. On histological examination, the tumor consisted of three different components; a lesion diagnosed as FA, another lesion as benign PT, and the other lesion as borderline PT. Finally, the tumor was diagnosed as borderline PT. Stromal cellularity may vary from area to area in any given PT. If there are some disagreements among the findings of imagings and cytology for the diagnosis of FA, as was seen in our case, the possibility of coexistence of PT should be considered.
This is a preview of subscription content, log in via an institution to check access.
Abbreviations
- PT:
-
Phyllodes tumor
- FA:
-
Fibroadenoma
- MRI:
-
Magnetic resonance imaging
- FNAC:
-
Fine needle aspiration cytology
- CNB:
-
Core needle Biopsy
- HPF:
-
High-power fields
References
McDaniel MD, Crichlow RW: Cystosarcoma phyllodes. In: Strombek SO, Rosato FE eds, Surgery of the Breast, Thienne Inc, New York, ppl51–152, 1986.
Haagensen CD: Cystos,arcoma phyllodes. In: Haagensen CD ed, Diseases of the Breast, WB Saunders, New York, pp284–312, 1986.
Noguchi S, Aihara T, Motomura K, Inaji H, Imaoka S, Koyama H, Kasugai T, Wada A: Phyllodes Tumor of the Breast: Pathology, Histogenesis, Diagnosis, and Treatment.Breast Cancer 3: 79–92, 1996.
Barth RJ Jr.: Histologic features predict local recurrence after breast conserving therapy of phyllodes tumors.Breast Cancer Res Treat 57: 291–295, 1999.
Dixon JM: Cystic disease and fibroadenoma of the breast: natural history and relation to breast cancer risk.Br Med Bull 47: 258–271, 1991.
Yilmaz E, Sal S, Lebe B: Differentiation of phyllodes tumors versus fibroadenomas.Acta Radiol 43: 34–39, 2002.
Scolyer RA, McKenzie PR, Achmed D, Lee CS: Can phyllodes tumours of the breast be distinguished from fibroadenomas using fine needle aspiration cytology?Pathology 33: 437–443, 2001.
Jayaram G, Sthaneshwar P: Fine-needle aspiration cytology of phyllodes tumors.Diagnostic Cytopathology 26: 222–227, 2002.
Veneti S, Manek S: Benign phyllodes tumour vs fibroadenoma: FNA cytological differentiation.Cytopathology 12: 321–328, 2001.
Simi U, Moretti D, Iacconi P, Arganini M, Roncella M, Miccoli P, Giacomini G: Fine aspiration cytology of phyllodes tumor. Differential diagnosis with fibroadenoma.Acta Cytologica 32: 63–66, 1988.
Komenaka IK, El-Tamer M, Pile-Spellman E, Hibshoosh H: Core needle biopsy as a diagnostic tool to differentiate phyllodes tumor from fibroadenoma.Arch Surg 138: 987–990, 2003.
Rosen PP Fibroepithelial neoplasms. In: Rosen PP ed, Rosen’s Breast Pathology, 2nd ed, Lippincott Williams & Wilkins Co, Philadelphia, ppl63–200, 2001.
Grimes MM: Cystosarcoma phyllodes of the breast: histologic features, flow cytometric analysis, and clinical correlations.Mod Pathol 5: 232–239, 1992.
Noguchi S, Motomura K, Inaji H, Imaoka S, Koyama H: Clonal analysis of fibroadenoma and phyllodes tumor of the breast.Cancer Res 53: 4071–4074, 1993.
Author information
Authors and Affiliations
About this article
Cite this article
Tomimaru, Y., Komoike, Y., Egawa, C. et al. A case of phyllodes tumor of the breast with a lesion mimicking fibroadenoma. Breast Cancer 12, 322–326 (2005). https://doi.org/10.2325/jbcs.12.322
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.2325/jbcs.12.322