Abstract
Background
Liver metastases from breast cancer are associated with a poor prognosis, however, local control with microwave thermocoagulation therapy has been used in certain subgroups of these patients in the past decade. In this study, open-configuration magnetic resonance (MR) -guided microwave thermocoagulation therapy was used for metastatic liver tumors from breast cancer, and the efficacy of this treatment was assessed.
Methods
Between June 2000 and April 2004, we used MR-guided microwave thermocoagulation therapy on 11 nodules in 8 patients with metastatic liver tumors from breast cancer. The procedure was carried out under general anesthesia. A 0.5 T open-configuration MR system and a microwave coagulator were used. Near-real-time MR images and real-time temperature images were collected and displayed on the monitor. The MR-compatible thoracoscope was used and combined with MR imaging guidance. Navigation software, a 3D Slicer, was installed and customized
Results
The customized navigation software displayed near-real-time MR images. The percutaneous puncture into the tumors was successful in all cases. No mortality or major complications occurred as a result of the procedures. Five of the 8 patients are alive with new metastatic foci with a mean observation period of 25.9 months.
Conclusions
We developed several devices to allow safe, easy, and accurate MR-guided microwave thermocoagulation therapy of liver tumors. Open-configuration MR-guided microwave thermocoagulation therapy appears to be a feasible method for tumor ablation of metastatic liver tumors from breast cancer.
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Abbreviations
- MR:
-
Magnetic resonance
- RF:
-
Radio-frequency
References
Zinser JW, Hortobagyi GN, Buzdar AU, Smith TL, Fraschini G: Clinical course of breast cancer patients with liver metastasis.J Clin Oncol 5:773–782, 1987.
Hoe AL, Royle GT, Taylor I: Breast liver metastases: incidence, diagnosis and outcome.J Soc Med 84:714–716, 1991.
Elias D, Lasser PH, Montrucolli D, Bonvallot S, Spielmann M: Hepatectomy for liver metastases from breast cancer.Eur J Surg Oncol 21:510–513, 1995.
Yoshimoto M, Sugitani I, Iwase T, Watanabe S, Kasumi F: Therapeutic efficacy of hepatectomy in the treatment of hepatic metastases from breast cancer.J Jpn Surg Soc 96:174–179, 1995 (in Japanese with English abstract).
Livraghi T, Vettori C, Lazzaroni S: Liver metastases: Result of percutaneous ethanol injection in 14 patients.Radiology 179:709–712,1991.
Ravikumar TS, Kane R, Cady B, Jenkins RL, McDermott W, Onik G, Clouse M, Steele G Jr: Hepatic cryosurgery with intraoperative ultrasound monitoring for metastatic colon carcinoma.Arch Surg 122:403–409, 1987.
Nolsoe CP, Torp-Pedersen S, Burcharth F, Horn T, Pedersen S, Christensen NE, Olldag ES, Andersen PH, Karstrup S, Lorentzen T: Interstitial hyperthermia of colorectal liver metastases with a US-guided Nd- YAG laser with a diffuser tip: a pilot clinical study.Radiology 187:333–337, 1993.
Rossi S, Di Stasi M, Buscarini E, Quaretti P, Garbagnati F, Squassante L, Paties CT, Silverman DE, Buscarini L: Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer.A J R 167:759–768, 1996.
Tabuse K: A new operative procedure of hepatic surgery using a microwave tissue coagulator.Arch Jpn Chir 48:160–172, 1979.
Schenck JF, Jolesz FA, Roemer PB, Cline HE, Lorensen WE, Kikinis R, Silverman SG, Hardy CJ, Barber WD, Laskaris: Superconducting open-configuration MR imaging system for image-guided therapy.Radiology 195:805–814, 1995.
Morikawa S, Inubushi T, Kurumi Y, Naka S, Sato K, Tani T, Yamamoto I, Fujimura M: MR-guided microwave thermocoagulation therapy of liver tumors: initial clinical experiences using a 0.5 T open MR system.J Magn Reson Imaging 16:576–583, 2002.
De Poorter J, De Wagner C, De Deene Y, Thomsen C, Stahlberg F, Achten E: Noninvasive MRI thermometry in human muscle.Magn Reson Med 33:74–81, 1995.
Jolesz FA, Nabavi A, Kikinis R: Integration of interventional MRI with computer-assisted surgery.J Magn Reson Imaging 13:69–77, 2001.
Gering DT, Nabavi A, Kikinis R, Hata N, O#x2019;Donnell LJ, Grimson WE, Jolesz FA, Black PM, Wells WM 3rd: An integrated visualization system for surgical planning and guidance using image fusion and an open MR.J Magn Reson Imaging 13:967–975, 2001.
Morikawa S, Inubushi T, Kurumi Y, Naka S, Sato K, Demura K, Tani T, Haque HA, Tokuda J, Hata N: Advanced computer assistance for magnetic resonance-guided microwave thermocoagulation of liver tumors.Acad Radiol 10:1442–1449, 2003.
Moriarty JA,Chen JC, Purcell CM, Ang LC, Hinks RS, Peters RD, Henkelman RM, Plewes DB, Bronskill MJ, Kucharczyk W: MR monitoring of interstitial microwave-induced heating and thermal lesions in rabbit brain in vivo.J Magn Reson Imaging 8:128–135, 1998.
Seki T, Wakabayashi M, Nakagawa T, Itoh T, Shiro T, Kunieda K, Sato M, Uchiyama S, Inoue K: Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma.Cancer 74:817–825, 1994.
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Abe, H., Kurumi, Y., Naka, S. et al. Open-configuration MR-guided microwave thermocoagulation therapy for metastatic liver tumors from breast cancer. Breast Cancer 12, 26–31 (2005). https://doi.org/10.2325/jbcs.12.26
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DOI: https://doi.org/10.2325/jbcs.12.26