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Breast Cancer

, 14:109 | Cite as

Squamous cell carcinoma of the breast in the form of an intracystic tumor

  • Takashi Shigekawa
  • Hitoshi Tsuda
  • Kazuhiko Sato
  • Shigeto Ueda
  • Hideki Asakawa
  • Rena Shigenaga
  • Hoshio Hiraide
  • Hidetaka Mochizuki
Case Report

Abstract

Squamous cell carcinoma of the breast is thought to arise through metaplasia of ductal carcinoma cells. We report a case of pure squamous cell carcinoma of the breast with features of intracystic tumor, which was considered to have arisen from metaplastic squamous epithelial cells lining the cyst wall. A 71-year-old woman presented at our hospital with a 40 × 30-mm mass in the lower outer quadrant of the right breast. Mammography revealed a round, high-density mass, which had a mostly regular but partially irregular margin. Ultrasonography demonstrated a solid tumor with an irregular shape protruding into a cystic space, suspicious of intracystic carcinoma. Aspiration cytology confirmed squamous cell carcinoma. A modified radical mastectomy was performed. Histopathologically, the intracystic tumor was a pure squamous cell carcinoma. The epithelial cells lining the inner cyst wall showed mostly squamous metaplasia, and there was continuity between these cells and the squamous cell carcinoma. 13 months later, the patient is free of disease with no adjuvant therapy.

Key words

Squamous cell carcinoma Intracystic tumor 

Abbreviations

SqCC

Squamous cell carcinoma

CIS

Carcinoma in situ

References

  1. 1).
    Tavassoli FA, Devilee P, Eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press, Lyon, pp38–39, 2003.Google Scholar
  2. 2).
    Toikkanen S: Primary squamous cell carcinoma of the breast.Cancer 48:1629–1632, 1981.CrossRefGoogle Scholar
  3. 3).
    Macia M, Ces JA, Becerra E, Novo A: Pure squamous carcinoma of the breast; report of a case diagnosed by aspiration cytology.Acta Cytol 33:201–204, 1989.PubMedGoogle Scholar
  4. 4).
    Cornog JL, Mobini J, Steiger E, Enterline HT: Squamous carcinoma of the breast.Am J Clin Pathol 55:410–417, 1971.CrossRefGoogle Scholar
  5. 5).
    Wargotz ES, Norris HJ: Metaplastic carcinoma of the breast. Squamous cell carcinoma of ductal origin.Cancer 65:272–276, 1990.CrossRefGoogle Scholar
  6. 6).
    Hasleton PS, Misch KA, Vasudev KS, George D: Squamous carcinoma of the breast.J Clin Pathol 31:116–124, 1978.CrossRefGoogle Scholar
  7. 7).
    Jones EL: Primary squamous-cell carcinoma of the breast with pseudosarcomatous stroma.J Pathol 97:383–385, 1969.CrossRefGoogle Scholar
  8. 8).
    Arffmann E, Hojgaard K: Squamous carcinoma of the breast: Report of a case.J Pathol Bacteriol 90:319–321, 1965.CrossRefGoogle Scholar
  9. 9).
    Soderstrom KO, Toikkanen S: Extensive squamous metaplasia simulating squamous cell carcinoma in benign breast papillomatosis.Hum Pathol 14:1081–1082, 1983.CrossRefGoogle Scholar
  10. 10).
    Woodard BH, Brinkhous AD, McCarty KS Jr, McCarty KS Jr: Adenosquamous differentiation in mammary carcinoma; an ultrastructural and steroid receptor study.Arch Pathol Lab Med 104:130–133, 1980.PubMedGoogle Scholar

Copyright information

© The Japanese Breast Cancer Society 2007

Authors and Affiliations

  • Takashi Shigekawa
    • 1
    • 4
  • Hitoshi Tsuda
    • 2
  • Kazuhiko Sato
    • 1
  • Shigeto Ueda
    • 1
  • Hideki Asakawa
    • 1
  • Rena Shigenaga
    • 1
  • Hoshio Hiraide
    • 3
  • Hidetaka Mochizuki
    • 1
  1. 1.Departments of Surgery INational Defense Medical CollegeJapan
  2. 2.Departments of Pathology IINational Defense Medical CollegeJapan
  3. 3.Research InstituteNational Defense Medical CollegeJapan
  4. 4.Department of Breast OncologySaitama Medical University, School of MedicineMoroyama, Iruma-gun, SaitamaJapan

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