Breast Cancer

, Volume 13, Issue 2, pp 225–229 | Cite as

A case of breast cancer metastatic to the tail of the pancreas

  • Noriyuki Tohnosu
  • Kazuo Narushima
  • Keita Sunouchi
  • Takeshi Saito
  • Takanori Shimizu
  • Hajime Tanaka
  • Takashi Maruyama
  • Yoshiji Watanabe
  • Taku Kato
  • Shinichiro Shimizu
  • Toshitaka Uehara
  • Satoru Ishii
Case Report

Abstract

Breast cancer metastasis to pancreas is rarely seen. There have been only 6 cases described in the literature. We present the seventh case of a 54-year-old woman with breast cancer that metastasized to the tail of the pancreas 4 years and 4 months after radical mastectomy. Although the serum levels of CA15-3 and TPA had gradually increased without symptoms, it was difficult to establish the diagnosis before contrast-enhanced abdominal CT scan was performed.

Immunohistochemical staining using E-cadherin was positive, proving that the breast cancer was ductal rather than lobular in origin. CA15-3 immunohistochemically stained positive in the resected pancreas lesion. Positive monoclonal staining by GCDFP-15 (gross cystic disease fluid protein-15) in the pancreas tumor also confirmed it breast cancer origin.

Investigation of chemokine/chemokine receptors may clarify a new mechanism of metastasis to the pancreas from breast cancer.

Key words

Recurrent breast cancer Metastasis to the pancreas tail Immunohistochemical staining of CA15-3 E-cadherin and GCDFP-15 

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Copyright information

© The Japanese Breast Cancer Society 2006

Authors and Affiliations

  • Noriyuki Tohnosu
    • 1
  • Kazuo Narushima
    • 1
  • Keita Sunouchi
    • 1
  • Takeshi Saito
    • 1
  • Takanori Shimizu
    • 1
  • Hajime Tanaka
    • 1
  • Takashi Maruyama
    • 1
  • Yoshiji Watanabe
    • 1
  • Taku Kato
    • 2
  • Shinichiro Shimizu
    • 2
  • Toshitaka Uehara
    • 2
  • Satoru Ishii
    • 3
  1. 1.Department of SurgeryFunabashi Municipal Medical CenterChibaJapan
  2. 2.Laboratory Division of PathologyFunabashi Municipal Medical CenterJapan
  3. 3.Division of RadiologyFunabashi Municipal Medical CenterJapan

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