Skip to main content
SpringerLink
Log in

Obesity and Its Impact on Drug Therapy

Are We Ready for This Change?

  • Commentary
  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Centers for Disease Control and Prevention. Overweight and obesity: data and statistics. US obesity trends [online]. Available from URL: http://www.cdc.gov/obesity/data/trends.html [Accessed 2011 Sep 9]

  2. Flegal KM, Carroll MD, Ogden CL, et al. Prevalence and trends in obesity among US adults, 1999–2008. JAMA 2010; 303(3): 235–41

    Article  PubMed  CAS  Google Scholar 

  3. Olds T, Maher C, Zumin S, et al. Evidence that the prevalence of childhood overweight is plateauing: data from nine countries. Int J Pediatr Obes 2011; 6(5–6): 342–60

    Article  PubMed  Google Scholar 

  4. Cheymol G. Effects of obesity on pharmacokinetics implications for drug therapy. Clin Pharmacokinet 2000; 39(3): 215–31

    Article  PubMed  CAS  Google Scholar 

  5. Hanley MJ, Abernethy DR, Greenblatt DJ. Effect of obesity on the pharmacokinetics of drugs in humans. Clin Pharmacokinet 2010; 49(2): 71–87

    Article  PubMed  CAS  Google Scholar 

  6. Ghobadi C, Johnson TN, Aarabi M, et al. Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance. Clin Pharmacokinet 2011; 50(12): 809–22

    Article  PubMed  CAS  Google Scholar 

  7. Zhao P, Zhang L, Grillo JA, et al. Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. Clin Pharmacol Ther 2011; 89(2): 259–67

    Article  PubMed  CAS  Google Scholar 

  8. Jiang W, Kim S, Zhang X, et al. The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation. Int J Pharm 2011; 418(2): 151–60

    Article  PubMed  CAS  Google Scholar 

  9. Mortensen A, Lenz K, AbildstrØm H, et al. Anesthetizing the obese child. Paed Anaesth 2011; 21(6): 623–9

    Article  Google Scholar 

  10. Mulla H, Johnson TN. Dosing dilemmas in obese children. Arch Dis Child Educ Pract Ed 2010; 95(4): 112–7

    Article  PubMed  CAS  Google Scholar 

  11. Anderson BJ, Holford NHG. Tips and traps analyzing pediatric PK data. Paed Anaesth 2011; 21(3): 222–37

    Article  Google Scholar 

  12. Jain R, Chung SM, Jain L, et al. Implications of obesity for drug therapy: limitations and challenges. Clin Pharmacol Ther 2011; 90(1): 77–89

    Article  PubMed  CAS  Google Scholar 

  13. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259(5091): 87–91

    Article  PubMed  CAS  Google Scholar 

  14. Hotamisligil GS, Arner P, Caro JF, et al. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95(5): 2409–15

    Article  PubMed  CAS  Google Scholar 

  15. Hotamisligil GS, Johnson RS, Distel RJ, et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 1996; 274(5291): 1377–9

    Article  PubMed  CAS  Google Scholar 

  16. Florez H, Castillo-Florez S, Mendez A, et al. C-reactive protein is elevated in obese patients with the metabolic syndrome. Diabetes Res Clin Pract 2006; 71(1): 92–100

    Article  PubMed  CAS  Google Scholar 

  17. Trayhurn P, Wood IS. Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 2005; 33(Pt 5): 1078–81

    PubMed  CAS  Google Scholar 

  18. Aitken AE, Morgan ET. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos 2007; 35(9): 1687–93

    Article  PubMed  CAS  Google Scholar 

  19. Sugioka N, Haraya K, Fukushima K, et al. Effects of obesity induced by high-fat diet on the pharmacokinetics of nelfinavir, a HIV protease inhibitor, in laboratory rats. Biopharm Drug Dispos 2009; 30(9): 532–41

    Article  PubMed  CAS  Google Scholar 

  20. Cheng Q, Aleksunes LM, Manautou JE, et al. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm 2008; 5(1): 77–91

    Article  PubMed  CAS  Google Scholar 

  21. Geier A, Dietrich CG, Grote T, et al. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. J Hepatol 2005; 43(6): 1021–30

    Article  PubMed  CAS  Google Scholar 

  22. Le Vee M, Gripon P, Stieger B, et al. Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Drug Metab Dispos 2008; 36(2): 217–22

    Article  PubMed  Google Scholar 

  23. Vee ML, Lecureur V, Stieger B, et al. Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6. Drug Metab Dispos 2009; 37(3): 685–93

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

Dr Neely holds an academic licence for Simcyp software. He has received no monetary support from Simcyp. Dr Louie has no conflicts of interest that are directly relevant to the content of this commentary.

Author information

Authors and Affiliations

  1. Keck School of Medicine, University of Southern California, Los Angeles, California, USA

    Michael Neely

  2. School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, California, 90033, USA

    Stan Louie

Authors
  1. Michael Neely
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stan Louie
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stan Louie.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Neely, M., Louie, S. Obesity and Its Impact on Drug Therapy. Clin Pharmacokinet 50, 825–826 (2011). https://doi.org/10.2165/11597120-000000000-00000

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/11597120-000000000-00000

Keywords

Search

Navigation