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Management of Pediatric Eosinophilic Esophagitis

An Update

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Abstract

Eosinophilic esophagitis is an important chronic esophageal disorder with gastroesophageal reflux disease (GERD)-like symptoms, prominent esophageal mucosal eosinophilia, strongly associated with allergic disorders and unresponsive to anti-GERD therapy. Treatment of eosinophilic esophagitis has been successful with the use of dietary restrictions and topical corticosteroids. A subset of patients benefits from concurrent anti-GERD therapy; those with demonstrable esophageal strictures report variable duration symptom relief after esophageal dilation. At the current time, anti-interleukin-5 monoclonal antibody agents are being investigated in multicenter trials, and it is hoped that future therapy may be targeted against mediators of esophageal remodeling and fibrosis in eosinophilic esophagitis.

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Acknowledgments

No sources of funding were used to prepare this manuscript. The author has no conflicts of interest that are directly relevant to the content of this review.

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  1. Division of Gastroenterology, Hepatology and Nutrition, Children’s National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA

    Seema Khan

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Khan, S. Management of Pediatric Eosinophilic Esophagitis. Pediatr Drugs 14, 23–33 (2012). https://doi.org/10.2165/11595210-000000000-00000

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