Abstract
Aging is associated with alterations in insulin secretion and action. However, aging per se does not alter the pharmacokinetics of commercially available insulin and its analogues. Insulin therapy in older adults is complicated by psychosocial and physiological changes of aging. Several new insulin and insulin analogue preparations are now available for clinical use. Used as prandial (e.g. insulin lispro, insulin aspart or insulin glulisine) and basal insulin (e.g. insulin glargine, insulin detemir), these analogues simulate physiological insulin profiles more closely than the older conventional insulins.
The availability of multiple insulin products provides new opportunities to achieve control of diabetes mellitus. The choice of initial insulin therapy can be made based on blood glucose profiles. Overall, these profiles can be divided into three general patterns that include: (i) round-the-clock hyperglycaemia; (ii) fasting hyperglycaemia with daytime euglycaemia; and (iii) daytime hyperglycaemia with normal fasting blood glucose levels. The prescription of insulin is a dynamic process, and the insulin regimen should be adjusted based on individual response. The goal of diabetes care in older adults is to enhance quality of life without subjecting individuals to complicated treatment regimens that may interfere with their independence in carrying out daily activities.
Similar content being viewed by others
References
Paolisso G. Pathophysiology of diabetes in elderly people. Acta Biomed 2010; 81Suppl. 1: 47–53
Mooradian AD. Mechanisms of age-related endocrine alterations: part II. Drugs Aging 1993; 3: 131–46
Saudek CD, Hill Golden S. Feasibility and outcomes of insulin therapy in elderly patients with diabetes mellitus. Drugs Aging 1999; 14: 375–85
Mooradian AD, Bernbaum M, Albert SG. A narrative review: a rational approach to starting insulin therapy. Ann Intern Med 2006; 145: 125–34
Cayea D, Boyd C, Durso SC. Individualizing therapy for older adults with diabetes mellitus. Drugs Aging 2007; 24: 851–63
Maty SC, Fried LP, Volpato S, et al. Patterns of disability related to diabetes mellitus in older women. J Gerontol A Biol Sci Med Sci 2004; 59: 148–53
Blaum CS, Ofstedal MB, Langa KM, et al. Functional status and health outcomes in older Americans with diabetes mellitus. J Am Geriatr Soc 2003; 51: 745–53
Blaum CS, Xue QL, Tian J, et al. Is hyperglycemia associated with frailty status in older women? J Am Geriatr Soc 2009; 57:840–7
Wray LA, Ofstedal MB, Langa KM, et al. The effect of diabetes on disability in middle-aged and older adults. J Gerontol A Biol Sci Med Sci 2005; 60: 1206–11
Volpato S, Leveille SG, Blaum C, et al. Risk factors for falls in older disabled women with diabetes: the women’s health and aging study. J Gerontol A Biol Sci Med Sci 2005; 60: 1539–45
Schwartz AV, Vittinghoff E, Sellmeyer DE, et al., Health, Aging, and Body Composition Study: diabetes-related complications, glycemic control, and falls in older adults. Diabetes Care 2008; 31: 391–6
Arvanitakis Z, Wilson RS, Bienias JL, et al. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 2004; 61: 661–6
Feil D, Weinreb J, Sultzer D. Psychiatric disorders and psychotropic medication use in elderly persons with diabetes. Ann Long Term Care 2006; 14: 39–47
Brown JS, Vittinghoff E, Lin F, et al. Prevalence and risk factors for urinary incontinence in women with type 2 diabetes and impaired fasting glucose: findings from the National Health and Nutrition Examination Survey (NHANES) 2001–2002. Diabetes Care 2006; 29: 1307–12
Mooradian AD. Drug therapy of non-insulin-dependent diabetes mellitus in the elderly. Drugs 1996; 6: 931–41
Chehade JM, Mooradian AD. A rational approach to drug therapy of type 2 diabetes mellitus. Drugs 2000; 60: 95–113
Oiknine R, Mooradian AD. Drug therapy of diabetes in the elderly. Biomed Pharmacother 2003; 57: 231–9
Chehade J, Mooradian AD. Drug therapy: current and emerging agents for hyperglycemia. In: Sinclair AJ, editor. Diabetes in old age. 3rd ed. Chichester: John Wiley & Sons, 2009: 245–64
Abbatecola AM, Paolisso G, Corsonello A, et al. Anti-diabetic oral treatment in older people: does frailty matter? Drugs Aging 2009; 26Suppl. 1: 53–62
Drab SR. Incretin-based therapies for type 2 diabetes mellitus: current status and future prospects. Pharmacotherapy 2010; 30: 609–24
Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368: 1696–705
Abbatecola AM, Maggi S, Paolisso G. New approaches to treating type 2 diabetes mellitus in the elderly: role of incretin therapies. Drugs Aging 2008; 25: 913–25
Ryan G, Briscoe TA, Jobe L. Review of pramlintide as adjunctive therapy in treatment of type 1 and type 2 diabetes. Drug Des Devel Ther 2009; 2: 203–14
Oiknine R, Bernbaum M, Mooradian AD. A critical appraisal of the role of insulin analogues in the management of diabetes. Drugs 2005; 65: 325–40
Howey DC, Bowsher RR, Brunelle RL, et al. (Lys(B28), Pro(B29))-human insulin: a rapidly absorbed analogue of human insulin. Diabetes 1994; 43: 396–402
Chapman TM, Noble S, Goa KL. Insulin aspart: a review of its use in the management of type 1 and 2 diabetes mellitus. Drugs 2002; 62: 1945–81
Barlocco D. Insulin glulisine Aventis Pharma. Curr Opin Investigat Drugs 2003; 4:1240–4
Ristic S, Bates PC. Effects of rapid-acting insulin analogs on overall glycemic control in type 1 and type 2 diabetes mellitus. Diabetes Technol Ther 2003; 5: 57–66
Rami B, Schober E. Postprandial glycaemia after regular and lispro insulin in children and adolescents with diabetes. Eur J Pediatr 1997; 156: 838–40
Heinemann L, Sinha K, Weyer C, et al. Time-action profile of the soluble, fatty acid acylated, long-acting insulin analogue NN304. Diabetic Med 1999; 16: 332–8
Kurtzhals P, Haveland S, Jonassen I, et al. Albumin binding and time action of acylated insulins in various species. J Pharma Sci 1996; 85: 304–8
Plank J, Bodenlenz M, Sinner F, et al. A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. Diabetes Care 2005; 28: 1107–12
Dunn CJ, Plosker GL, Keating GM, et al. Insulin glargine: an updated review of its use in the management of diabetes mellitus. Drugs 2003; 63:1743–78
Gerich JE. Insulin glargine: long-acting basal insulin analog for improved metabolic control. Curr Med Res Opin 2004; 20: 31–7
Hamann A, Matthaei S, Rosak C, et al., HOE901/4007 Study Group. A randomized clinical trial comparing breakfast, dinner, or bedtime administration of insulin glargine in patients with type 1 diabetes. Diabetes Care 2003; 26: 1738–44
Yki-Jarvinen H, Dressler A, Ziemen M. Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. Diabetes Care 2000; 23: 1130–6
Riddle M, Rosenstock J, Gerich J. The treat-to-target trial. Diabetes Care 2003; 26: 3080–6
Janka HU, Plewe G, Busch K. Combination of oral anti-diabetic agents with basal insulin versus premixed insulin alone in randomized elderly patients with type 2 diabetes mellitus. J Am Geriatr Soc 2007; 55: 182–8
Heise T, Weyer C, Serwas A, et al. Time-action profiles of novel premixed preparations of insulin lispro and NPL insulin. Diabetes Care 1998; 21: 800–3
Rosenstock J, Cefalu WT, Hollander PA, et al. Safety and efficacy of inhaled human insulin (Exubera) during discontinuation and readministration of therapy in adults with type 2 diabetes: a 3-year randomized controlled trial. Diabetes Technol Ther 2009; 11: 697–705
Rave K, Potocka E, Boss AH, et al. Pharmacokinetics and linear exposure of AFRESA compared with the subcutaneous injection of regular human insulin. Diabetes Obes Metab 2009; 11: 715–20
Pozzilli P, Raskin P, Parkin CG. Review of clinical trials: update on oral insulin spray formulation. Diabetes Obes Metab 2010; 12:91–6
Mannucci E, Monami M, Balzi D, et al. Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care 2010; 33: 1997–2003
Banks WA, Morley JE, Lynch JL, et al. Insulin detemir is not transported across the blood-brain barrier. Peptides 2010; 31: 2284–8
Mooradian AD, Chehade JM. Diabetes mellitus in older adults. Am J Ther. Epub 2011 Jan 18
Jamali R, Bachrach-Lindström M, Mohseni S. Continuous glucose monitoring system signals the occurrence of marked postprandial hyperglycemia in the elderly. Diabetes Technol Ther 2005; 7: 509–15
Monnier L, Colette C, Boegner C, et al. Continuous glucose monitoring in patients with type 2 diabetes: Why? When? Whom? Diabetes Metab 2007; 33: 247–52
Horani MH, Mooradian AD. Management of obesity in the elderly: special considerations. Treat Endocrinol 2002; 1: 387–98
Herman WH, Ilag LL, Johnson SL, et al. A clinical trial of continuous subcutaneous insulin infusion versus multiple daily injections in older adults with type 2 diabetes. Diabetes Care 2005; 28: 1568–73
Janka HU, Plewe G, Riddle MC, et al. Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes. Diabetes Care 2005; 28: 254–9
Raskin P, Allen E, Hollander P, et al. INITIATE Study Group. Initiating insulin therapy in type 2 diabetes: a comparison of biphasic and basal insulin analogs. Diabetes Care. 2005; 28:260–5
Malone JK, Kerr LF, Campaigne BN, et al. Lispro Mixture-Glargine Study Group. Combined therapy with insulin lispro Mix 75/25 plus metformin or insulin glargine plus metformin: a 16-week randomized, open-label, crossover study in patients with type 2 diabetes beginning insulin therapy. Clin Ther 2004; 26: 2034–44
Clar C, Barnard K, Cummins E, et al., Aberdeen Health Technology Assessment Group. Self-monitoring of blood glucose in type 2 diabetes: systematic review. Health Technol Assess 2010; 14: 1–140
Thurman JE. Insulin pen injection devices for management of patients with type 2 diabetes: considerations based on an endocrinologist’s practical experience in the United States. Endocr Pract 2007; 13: 672–8
Bott U, Ebrahim S, Hirschberger S, et al. Effect of the rapid-acting insulin analogue insulin aspart on quality of life and treatment satisfaction in patients with type 1 diabetes. Diabetic Med 2003; 20: 626–34
Dunn CJ, Plosker GL. Insulin lispro: a pharmacoeconomic review of its use in diabetes mellitus. Pharmacoeconomics 2002; 20: 989–1025
Siebenhofer A, Plank J, Berghold A, et al. Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus. Cochrane Database Systematic Rev 2004; (2): CD003287
Durso SC. Using clinical guidelines for older adult patients with diabetes mellitus and complex health status. JAMA 2006; 295: 1935–40
American Diabetes Association. Diagnosis and classification of diabetes. Diabetes Care 2010; 33 Suppl. 1: S62–9
Huang ES, Gorawara-Bhat R, Chin MH. Self-reported goals of older patients with type 2 diabetes mellitus. J Am Geriatr Soc 2005; 53: 306–11
Maddigan SL, Feeny DH, Majumdar SR, et al. Understanding the determinants of health for people with type 2 diabetes. Am J Public Health 2006; 96: 1649–55
Acknowledgements
The author has no conflicts of interest that relate to the contents of this review. No funding was received for the preparation of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mooradian, A.D. Special Considerations with Insulin Therapy in Older Adults with Diabetes Mellitus. Drugs Aging 28, 429–438 (2011). https://doi.org/10.2165/11590570-000000000-00000
Published:
Issue Date:
DOI: https://doi.org/10.2165/11590570-000000000-00000