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Improved Blood Pressure Control in Elderly Hypertensive Patients

Results of the PAPY-65 Survey

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Abstract

Background Blood pressure (BP) control is far from optimal. Studies on factors influencing BP control in the elderly are limited, yet identification of factors contributing to the low rate of BP control is a prerequisite to improvement of clinical management.

Objective To evaluate the rate of BP control and the relationship between different clinical characteristics and BP control in treated hypertensive outpatients aged ≥65 years.

Methods The PAPY-65 Survey was a prospective cross-sectional survey conducted in primary care in Belgium in 2007. Participating primary-care physicians were required to include consecutive hypertensive patients aged ≥65 years and treated with antihypertensive drugs. Demographic and anthropometric data as well as data on cardiovascular risk factors and history were obtained. BP was measured in accordance with the European Society of Hypertension/European Society of Cardiology guidelines.

Results The mean±standard deviation (SD) age of the 1272 patients enrolled in the survey was 75±7 years; 702 (55%) patients were women. The mean±SD systolic/diastolic BP was 134/79±13/8 mmHg. BP was normalized (reduced to <140/90mmHg, or <130/80 mmHg in patients with diabetes mellitus) in 617 (48.5%) patients overall and in 88 (24%) patients with diabetes (n= 371). The majority of patients (921; 72%) were treated with two or more antihypertensive drugs. Both general obesity (body mass index ≥30 vs <25 kg/m2) and abdominal obesity were associated with lack of BP control (unadjusted odds ratio [OR] 2.988, 95% CI 2.200, 4.057 and OR 2.066, 95% CI 1.649, 2.588, respectively). Abdominal obesity was no longer related to BP control when adjusted for the presence of diabetes. Diabetes was strongly associated with lack of BP control only when a stringent definition of BP control (<130/80 mmHg) was used. The combined presence of subclinical organ damage and a history of cardiovascular disease was associated with less uncontrolled BP (OR 0.62, 95% CI 0.48, 0.80).

Conclusion Compared with previous data in the elderly in Belgium, a clear improvement in BP control was observed, probably related to the use of more antihypertensive agents. The presence of diabetes, excess bodyweight and abdominal obesity were all associated with poor BP control.

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Acknowledgements

The survey was conducted with the financial support of Bristol-Myers Squibb and Sanofi-Aventis. The authors gratefully acknowledge Marc Puttemans and Koen Jacobs, Medical Department of Sanofi-Aventis, and Claude Krygier, former physician at the Medical Department of Bristol-Myers Squibb, for their general input, the many primary-care physicians involved in the survey for their dedicated collaboration, Ron Brower and Karl Martin Wissing for their statistical help and Mrs Nadia Fenners for secretarial assistance. The authors have no conflicts of interest that are directly relevant to the content of this study.

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Authors and Affiliations

  1. Department of Nephrology and Hypertension, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, B-1090, Brussels, Belgium

    Patricia Van der Niepen

  2. Department of Clinical Pharmacology and Pharmacotherapy, Universitair Ziekenhuis Brussel, Brussels, Belgium

    Alain G. Dupont

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  1. Patricia Van der Niepen
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Correspondence to Patricia Van der Niepen.

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Van der Niepen, P., Dupont, A.G. Improved Blood Pressure Control in Elderly Hypertensive Patients. Drugs Aging 27, 573–588 (2010). https://doi.org/10.2165/11537350-000000000-00000

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