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A Case of Dystrophic Epidermolysis Bullosa Improved with Etanercept for Concomitant Psoriatic Arthritis

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Abstract

Epidermolysis bullosa is a group of inherited, chronic, non-inflammatory skin disorders, and dystrophic epidermolysis bullosa (DEB) is one of the most severe variants. The role of tumour necrosis factor alpha (TNFα) has not been reported in the pathogenesis of DEB. A DEB case is reported that appears to have responded well to the TNFα inhibitor etanercept given for the treatment of concomitant psoriatic arthritis. A progressive improvement in DEB was apparent over the first 3 months of treatment and persistent good control of DEB was noted over 3 years of therapy. A correlation between DEB improvement and etanercept has not been made, but the case may provide insight into the causal mechanisms of DEB.

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Acknowledgments

The authors would like to thank Stephanie Blick of inScience Communications who provided assistance with English-language editing. This assistance was funded by Pfizer. The authors report no conflicts of interest.

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Authors and Affiliations

  1. Istituto Dermopatico dell’Immacolata (IDI) IRCCS, Via dei Monti di Creta 104, Rome, 00167, Italy

    Emanuela Gubinelli, Corrado Angelo & Valeria Pacifico

Authors
  1. Emanuela Gubinelli
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  2. Corrado Angelo
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  3. Valeria Pacifico
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Correspondence to Emanuela Gubinelli.

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Gubinelli, E., Angelo, C. & Pacifico, V. A Case of Dystrophic Epidermolysis Bullosa Improved with Etanercept for Concomitant Psoriatic Arthritis. AM J Clin Dermatol 11 (Suppl 1), 53–54 (2010). https://doi.org/10.2165/1153427-S0-000000000-00000

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  • DOI: https://doi.org/10.2165/1153427-S0-000000000-00000

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