Abstract
Painful granulomatous lesions appeared on the face of a 36-year-old man with myelodysplastic syndrome. Skin biopsy revealed chronic inflammatory granuloma. Bacterial cultures of the lesions and blood indicated the same unknown Gram-negative rod bacterium. The 16S ribosomal RNA sequence of the unknown bacterium yielded Phenylobacterium. Thus, we diagnosed cutaneous infectious granuloma caused by Phenylobacterium and myelodysplastic syndrome/refractory cytopenia with multi-lineage dysplasia. After treatment with combined antibacterials that were selected based on the tests for drug sensitivity, the lesions disappeared with only scars remaining and without any signs of relapse after 1 year. This is the first case report of cutaneous infectious granuloma caused by Phenylobacterium.
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Acknowledgments
The authors thank Prof. Ju Li-wen, Department of Epidemiology of School of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China, for her assistance with the necessary research of bacterial cultures and organization of materials required to prepare this report. No sources of funding were used to assist in the preparation of this case report. The authors have no conflicts of interest that are directly relevant to the content of this case report.
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Zhu, Xh., Li, F., Xu, Jh. et al. Cutaneous Infectious Granuloma Caused by Phenylobacterium in an Adult with Myelodysplastic Syndrome. Am J Clin Dermatol 11, 363–366 (2010). https://doi.org/10.2165/11533200-000000000-00000
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DOI: https://doi.org/10.2165/11533200-000000000-00000