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Metformin for Atypical Antipsychotic-Induced Weight Gain and Glucose Metabolism Dysregulation

Review of the Literature and Clinical Suggestions

Abstract

Individuals receiving certain atypical antipsychotic medications are at risk of gaining weight and developing metabolic problems. There are no established drug treatments to prevent or counter these problems. However, the antihyperglycaemic agent metformin appears promising in some recent studies and we review the literature that evaluates metformin for limiting or reversing atypical antipsychotic drug-induced weight gain and glucose metabolism dysregulation. These studies suggest that metformin is beneficial if started early in antipsychotic drug treatment. Metformin has also been shown to prevent or delay the onset of type 2 diabetes mellitus in high-risk individuals from the general population. Based on these findings, we identify antipsychotic drug-treated patients who might benefit from metformin therapy and offer clinical guidelines for its use. Further long-term studies are needed to extend our observations and improve this strategy.

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No sources of funding were used to assist in the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review.

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Hasnain, M., Vieweg, W.V.R. & Fredrickson, S.K. Metformin for Atypical Antipsychotic-Induced Weight Gain and Glucose Metabolism Dysregulation. CNS Drugs 24, 193–206 (2010). https://doi.org/10.2165/11530130-000000000-00000

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Keywords

  • Metformin
  • Waist Circumference
  • Clozapine
  • Risperidone
  • Olanzapine