Abstract
Anidulafungin is an antifungal drug belonging to the echinocandin class with a potent in vitro fungicidal activity against a wide range of Candida species, including C. glabrata and C. krusei. Anidulafungin is also active in vitro against moulds belonging to the genus Aspergillus and some dematiaceous genera. Furthermore, anidulafungin demonstrates in vitro activity against Candida spp. growing as biofilms. Resistance to anidulafungin remains very rare based on recent epidemiological data. Paradoxical or trailing effects should be considered in echinocandin susceptibility testing. The in vitro activity profile of anidulafungin makes it a useful addition to the Italian antifungal armamentarium.
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References
Pfaller MA, Boyken L, Hollis RJ, et al. In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance. J Clin Microbiol 2008 Jan; 46(1): 150–6
Cohen-Wolkowiez M, Benjamin Jr DK, Steinback WJ, et al. Anidulafungin: a new echinocandin for the treatment of fungal infections. Drugs of Today 2006 Aug; 42(8): 533–44
Pfaller MA, Diekema DJ, Ostrosky-Zeichner L, et al. Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints. J Clin Microbiol 2008 Aug; 46(8): 2620–9
Perlin DS. Resistance to echinocandin-class antifungal drugs. Drugs Resist Updates 2007 Jun; 10(3): 121–30
Garcia-Effron G, Park S, Perlin DS. Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints. Antimicrob Agents Chemother 2009 Jan; 53(1): 112–22
Ruan SY, Chu CC, Hsueh PR. In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates. Antimicrob Agents Chemother 2008 Aug; 52(8): 2919–22
Pfaller MA, Boyken L, Hollis RJ, et al. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole. J Clin Microbiol 2005 Nov; 43(11): 5425–7
Jacobson MJ, Piper KE, Nguyen G, et al. In vitro activity of anidulafungin against Candida albicans biofilms. Antimicrob Agents Chemother 2008 Jun; 52(6): 2242–3
Katragkou A, Chatzimoschou A, Simitsopoulou M, et al. Differential activities of newer antifungal agents against Candida albicans and Candida parapsilosis biofilms. Antimicrob Agents Chemother 2008 Jan; 52(1): 357–60
Ghannoum MA, Chen A, Buhari M, et al. Differential in vitro activity of anidulafungin, caspofungin and micafungin against Candida parapsilosis isolates recovered from a burn unit. Clin Microbiol Infect 2009; 15: 274–9
Stevens DA, Espiritu M, Parmar R. Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations. Antimicrob Agents Chemother 2004 Sep; 48(9): 3407–11
Fleischhacker M, Radecke C, Schulz B, et al. Paradoxical growth effects of the echinocandins caspofungin and micafungin, but not of anidulafungin, on clinical isolates of Candida albicans and C. dubliniensis. Eur J Clin Microbiol Infect Dis 2008 Feb; 27(2): 127–31
Acknowledgements
The authors thank Andrea Bothwell of Wolters Kluwer Pharma Solutions who provided assistance with English language editing. This assistance was funded by Pfizer.
Dr Morace has acted as a consultant for MSD Italia and Pfizer Italia, received honoraria from MSD Italia, Pfizer Italia and Schering Plough Italia, and received a grant from Pfizer Italia. Dr Montagna has received honoraria from MSD Italia, Pfizer Italia, Schering Plough Italia and Gilead, and received a grant from Pfizer Italia. Drs Borghi and Iatta have no conflicts of interest to declare.
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Morace, G., Borghi, E., Iatta, R. et al. Anidulafungin, a New Echinocandin. Drugs 69 (Suppl 1), 91–94 (2009). https://doi.org/10.2165/11315560-000000000-00000
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DOI: https://doi.org/10.2165/11315560-000000000-00000