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Potential Influences of Complementary Therapy on Motor and Non-Motor Complications in Parkinson’s Disease

CNS Drugs volume 23, pages 817–835 (2009)Cite this article

Abstract

Nearly two-thirds of patients with Parkinson’s disease (PD) use vitamins or nutritional supplements, and many more may use other complementary therapies, yet <50% of patients have discussed the use of these complementary therapies with a healthcare professional. Physicians should be aware of the complementary therapies their patients with PD are using, and the possible effects of these therapies on motor and non-motor symptoms.

Complementary therapies, such as altered diet, dietary supplements, vitamin therapy, herbal supplements, caffeine, nicotine, exercise, physical therapy, massage therapy, melatonin, bright-light therapy and acupuncture, may all influence the symptoms of PD and/or the effectiveness of dopaminergic therapy. Preliminary evidence suggests complementary therapy also may influence non-motor symptoms of PD, such as respiratory disorders, gastrointestinal disorders, mood disorders, sleep and orthostatic hypotension. Whenever possible, clinicians should ensure that complementary therapy is used appropriately in PD patients without reducing the benefits of dopaminergic therapy.

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Acknowledgements

The preparation of this manuscript was supported by Novartis Pharmaceuticals Corporation. The authors would like to thank Jonathan Latham, of PharmaScribe, LLC, for assistance in the preparation of this manuscript. The authors had full control of the contents of the manuscript. Dr Zesiewicz has no conflicts of interest that are directly relevant to the content of this review. Dr Evatt has no conflicts of interest that are directly relevant to the contents of this review. She has received honoraria for speaking from NWGA Parkinson Disease Association, UCB and Allergan, and has received grants for studies from the Parkinson’s Study Group and Emory University, Boehringer Ingelheim, Merz, Santhera, Molecular Neuroimaging, LLC and Institute for Neurodegenerative Disorders, and Ipsen.

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  1. Parkinson Research Foundation, Department of Neurology, University of South Florida, 12901 Bruce B Downs Blvd MDC 55, Tampa, Florida, 33612, USA

    Theresa A. Zesiewicz

  2. Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA

    Marian L. Evatt

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  1. Theresa A. Zesiewicz
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  2. Marian L. Evatt
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Correspondence to Theresa A. Zesiewicz.

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Zesiewicz, T.A., Evatt, M.L. Potential Influences of Complementary Therapy on Motor and Non-Motor Complications in Parkinson’s Disease. CNS Drugs 23, 817–835 (2009). https://doi.org/10.2165/11310860-000000000-00000

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  • DOI: https://doi.org/10.2165/11310860-000000000-00000

Keywords

  • Levodopa
  • Creatine Supplementation
  • Complementary Therapy
  • Motor Complication
  • Yahr Stage