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Uncovering the Genetics of Systemic Lupus Erythematosus

Implications for Therapy

  • Genomics in Human Disease
  • Published:
American Journal of Pharmacogenomics

Abstract

Although it is well known that genetic factors contribute significantly to the expression of systemic lupus erythematosus (SLE) it was only recently realized, through genome-wide searches, that the number of involved genes is rather large. The published information hints at two facts: first, the number of genomic loci identified in various diverse cohorts is large and not necessarily overlapping; and second, certain loci may be preferentially linked with specific clinical manifestations. The latter may ultimately lead to a better understanding of the nature of the clinical entity that we know as SLE, and identification of groups of patients prone to respond better to treatment or to develop significant adverse effects. Advances attained regarding the nature of the biochemical and molecular defects that underwrite the aberrant function of immune cells parallel the progress made on the genetic origin of the disease. The genetic links need to be connected with aberrant function of their products to validate their significance. It is expected that correction of molecular aberrations either medicinally or by gene therapy will provide the needed specific treatment for patients with SLE.

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Acknowledgements

The opinions expressed herein represent those of the authors and not those of the Department of Defense. Work in the Tsokos Laboratory was supported by Public Health Service grants RO1 AI42269 and RO1 AI49964. None of the authors has any conflict of interest directly relevant to the content of this review.

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Authors and Affiliations

  1. Division of Rheumatology, Washington Hospital Center, Washington, DC, USA

    Vasileios C. Kyttaris &  George C. Tsokos

  2. Department of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, Maryland, 20814, USA

    Vasileios C. Kyttaris &  George C. Tsokos

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Correspondence to George C. Tsokos.

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Kyttaris, V.C., Tsokos, G.C. Uncovering the Genetics of Systemic Lupus Erythematosus. Am J Pharmacogenomics 3, 193–202 (2003). https://doi.org/10.2165/00129785-200303030-00005

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