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REFERENCE
Lin Y-H, Huang E, Chien Y-L.Bilateral pallidal necrosis and cardiac toxicity in a patient with venlafaxine and bupropion overdose. American Journal of Psychiatry 169: 993-994, No. 9, Sep 2012. Available from: URL: http://dx.doi.org/10.1176/appi.ajp.2012.11111708 - Taiwan
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COMMENT
Editorial Comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of pallidal necrosis associated with bupropion or venlafaxine. The WHO ADR database did not contain any reports of central nervous system necrosis associated with bupropion or venlafaxine.
Key words
Bupropion; Venlafaxine; drug-induced; Necrosis; overdose; Heart-disorders; Brain-disorders; Drug-overdose; Lorazepam
An event is serious (FDA MedWatch definition) when the patient outcome is: death; life-threatening; hospitalisation; disability; congenital anomaly; requires intervention to prevent permanent impairment or damage; First published case reportDrug overdo
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Bupropion/lorazepam/venlafaxine overdose. React. Wkly. 1426, 15 (2012). https://doi.org/10.2165/00128415-201214260-00049
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DOI: https://doi.org/10.2165/00128415-201214260-00049