Do certain antibacterials increase the risk of septic shock?

Abstract

While antibacterials are known to be effective in treating septicaemia induced by Gram-negative bacteria, treatment with certain antibacterials also appears to increase endotoxin release, which could have negative consequences. In both animal and clinical studies, researchers have shown that the amount of lipopolysaccharide endotoxin released by Gram-negative bacteria is influenced by the choice of antibacterial used. Endotoxins are key factors involved in the development of septic shock syndrome. However, in spite of these findings, researchers have not found a direct link between choice of antibacterial and septic shock outcome. In presentations at the 16th International Symposium on Intensive Care and Emergency Medicine [ Brussels, Belgium; March 1996 ], two researchers described recent investigations in this field.