Newer bisphosphonates show potential in Paget’s disease

Abstract

The bisphosphonates are potentially useful in many conditions where there is increased bone resorption. Several are either approved, or are in phase III clinical trials, for osteoporosis and hypercalcaemia associated with malignancy. Another condition that could benefit from these agents is Paget’s disease. This is a condition in which rapid turnover of bone leads to bone deformation and, sometimes, severe pain. At the 16th Annual Meeting of the American Society of Bone and Mineral Research [ Kansas City, US; September 1994 ], results of clinical trials for several of the newer bisphosphonates in Paget’s disease were presented.