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Coexistent Psoriasis and Lupus Erythematosus Treated with Alefacept

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Abstract

Coexistence of psoriasis and subacute cutaneous lupus erythematosus (SCLE) is unusual. Although there have been reports of this occurrence, there have been no reports of this overlap syndrome treated with immunomodulators. We describe a case of coexisting psoriasis and SCLE initially treated with infliximab, and then alefacept. The patient’s arthritis flared after the second infusion of infliximab, which was discontinued. During treatment with alefacept, the patient’s psoriasis improved markedly without exacerbation of his photosensitive SCLE lesions.

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Acknowledgments

This study was funded in part by the National Institute of Arthritis and Musculoskeletal and Skin Diseases K24-CA86815 (MD) and by the Sherry L. Anderson CTCL Patient Research Fund. The authors have no conflicts of interest that are directly relevant to the content of this study.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Texas Houston Health Science Center, Houston, Texas, USA

    Cindy Berthelot

  2. Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Jason Nash

  3. Department of Dermatology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 434, 77030-4009, Houston, Texas, USA

    Madeleine Duvic

Authors
  1. Cindy Berthelot
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  2. Jason Nash
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  3. Madeleine Duvic
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Correspondence to Madeleine Duvic.

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Berthelot, C., Nash, J. & Duvic, M. Coexistent Psoriasis and Lupus Erythematosus Treated with Alefacept. Am J Clin Dermatol 8, 47–50 (2007). https://doi.org/10.2165/00128071-200708010-00007

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  • DOI: https://doi.org/10.2165/00128071-200708010-00007

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