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American Journal of Clinical Dermatology

, Volume 6, Issue 6, pp 393–402 | Cite as

The Role of Hyaluronic Acid in Wound Healing

Assessment of Clinical Evidence
  • Richard D. Price
  • Simon Myers
  • Irene M. Leigh
  • Harshad A. NavsariaEmail author
Review Article

Abstract

Hyaluronic acid (hyaluronan), a naturally occurring polymer within the skin, has been extensively studied since its discovery in 1934. It has been used in a wide range of medical fields as diverse as orthopedics and cosmetic surgery, but it is in tissue engineering that it has been primarily advanced for treatment. The breakdown products of this large macromolecule have a range of properties that lend it specifically to this setting and also to the field of wound healing. It is non-antigenic and may be manufactured in a number of forms, ranging from gels to sheets of solid material through to lightly woven meshes. Epidermal engraftment is superior to most of the available biotechnologies and, as such, the material shows great promise in both animal and clinical studies of tissue engineering. Ongoing work centers around the ability of the molecule to enhance angiogenesis and the conversion of chronic wounds into acute wounds.

Keywords

Tissue Engineering Hyaluronic Acid Chronic Wound Pyoderma Gangrenosum Epidermolysis Bullosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Thank you to Fidia Advanced Biopolymers, Italy for figures 2, 3 and 4. Part of this work was supported by the BRITE-Euram grant BE3524. The authors have no conflicts of interest that are directly relevant to the content of this review.

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Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  • Richard D. Price
    • 1
    • 2
  • Simon Myers
    • 2
  • Irene M. Leigh
    • 2
  • Harshad A. Navsaria
    • 2
    Email author
  1. 1.South Manchester University Hospitals NHS TrustManchesterUK
  2. 2.Centre for Cutaneous Research, Queen Mary CollegeUniversity of LondonLondonUK

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