References
Cuzzolin L, Conforti A, Adami A. Anti-inflammatory potency and gastrointestinal toxicity of a new compound, nitronaproxen. Pharmacological Research 31: 61–65, Jan 1995
NicOx SA. NicOx to Reacquire Rights to CINOD Class of Drugs From AstraZeneca. Media Release: 23 Sep 2003. Available from URL: http://www.nicox.com
NicOx SA. NicOx Completes Enrolment of Phase 3 Trial for HCT 3012 in Osteoarthritis Ahead of Schedule. Media Release: 24 May 2006. Available from URL: http://www.nicox.com
NicOx SA. NicOx Initiates New Trial to Establish HCT 3012 as Osteoarthritis Treatment With Beneficial Blood Pressure Profile. Media Release: 4 May 2006. Available from URL: http://www.nicox.com
NicOx SA. NicOx Announces Initiation of Phase 3 Trial For HCT 3012 in Osteoarthritis. Media Release: 20 Dec 2005. Available from URL: http://www.nicox.com
NicOx SA. NicOx Reports 2004 Financial Results. Media Release: 1 Mar 2005. Available from URL: http://www.nicox.com
Nicox. NicOx Announces Positive Evaluation of Overall Phase II Clinical Results on AZD3582 by a U.S. Consultant Advisory Board. Media Release: 27 Jan 2004. Available from URL: http://www.nicox.com
NicOx. NicOx Initiates Clinical Study to Evaluate HCT 3012 Effects on Blood Pressure Vs. Rofecoxib. Media Release: 8 Sep 2004. Available from URL: http://www.nicox.com
Lohmander LS, McKeith D, Svensson O, et al. A randomised, placebo controlled, comparative trial of the gastrointestinal safety and efficacy of AZD3582 versus naproxen in osteoarthritis. Annals of the Rheumatic Diseases 64: 449–456, No. 3, Mar 2005
Schnitzer TJ, Kivitz AJ, Lipetz RS, et al. A phase II study of the efficacy and safety of AZD3582, a cinod, in subjects with osteoarthritis of the knee. Annals of the Rheumatic Diseases 63 (Suppl. 1): 62–63, Jul 2004
NicOx SA. NicOx Announces Preliminary Review of Data from Phase II Study of AZD3582. Media Release: 11 Mar 2003. Available from URL: http://www.nicox.com
NicOx SA. Further Update on AZD3582 Following Meeting of Independent Panel. Media Release: 26 Mar 2003. Available from URL: http://www.nicox.com
Fagerholm U, Andersson L, Swedmark S, et al. Pharmacokinetics of AZD3582, a COX-inhibiting nitric oxide donator, in animals suggest potential clinical utility as an analgesic drug. Pharmacologist 44 (Suppl. 1): 171, 2002
Schnitzer T, Ballabio M, Bonizzoni E. AZD3582, a CINOD, differs significantly from rofecoxib in having a neutral effect on blood pressure in patients with osteoarthritis: results of a randomized, controlled trial. Arthritis and Rheumatism 50 (Suppl.): 347, No. 9, Sep 2004
Cirino G, Wheeler-Jones CPD, Wallace JL. Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal antiinflammatory derivatives with gastrointestinal-sparing properties. British Journal of Pharmacology 117: 1421–1426, Apr 1996
Cirino G, Calignano A, Iannaro A. NO-naproxen modulates inflammation pain and T cell response in rat Freund’s adjuvant arthritis. Mediators of Inflammation 8 (Suppl. 1): 59, 1999
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Nitronaproxen. Drugs in R D 7, 262–266 (2006). https://doi.org/10.2165/00126839-200607040-00007
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DOI: https://doi.org/10.2165/00126839-200607040-00007