References
Adolor Corporation, GlaxoSmithKline. Adolor and Glaxo-SmithKline announce worldwide development and commer-cialization agreement for alvimopan. Media Release: 15 Apr 2002. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Reports Initial Results from GSK European Phase 3 Study of Alvimopan. Media Release: 23 Dec 2004. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Submits First Portion of NDA for Entereg(TM) (alvimopan) in Postoperative Ileus. Media Release: 7 May 2004. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Completes Submission of NDA for Entereg (TM) (alvimopan) in Postoperative Ileus. Media Release: 28 Jun 2004. Available from URL: http://www.adolor.com
Adolor Corporation. FDA Extends PDUFA Action Date for Entereg(TM) (alvimopan) Capsules to July 25, 2005. Media Release: 19 Apr 2005. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Receives FDA Approvable Letter for Entereg(R) (Alvimopan). Media Release: 22 Jul 2005. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Announces FDA Update. Media Release: 10 Jan 2005. Available from URL: http://www.adolor.com
Adolor Corporation, GlaxoSmithKline Corporation. Adolor and GlaxoSmithKline Report Positive Top-Line Results in Phase 3 Study 314 of Entereg(R) (Alvimopan) in Postoperative Ileus. Media Release: 7 Feb 2006. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Corporation Announces Top-Line Results in Entereg(TM) Phase 3 Clinical Study 308 in Postop-erative Ileus. Media Release: 13 Jan 2004. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Corporation Announces Top-Line Results In Phase 3 Safety Study of Entereg(TM) (alvimopan) in Postoperative Ileus. Media Release: 22 Oct 2003. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Corporation Receives Patents Covering Novel Uses and Compositions Containing Alvimopan. Media Release: 13 Nov 2002. Available from URL: http://www.alolor.com
Zimmerman DM, Gidda JS, Cantrell BE. LY246736 dihydrate: mu opioid receptor antagonist. Drugs of the Future 19: 1078–1083, Dec 1994
Adolor Corporation. Adolor Corporation completes phase 2 clinical trials in post-operative ileus second phase 3 pivotal clinical trial to begin shortly. Media Release [3 pages], 28 Jun 2001. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Corporation Announces Topline Results of Alvimopan Phase 3 Study in Opioid Bowel Dysfunction. Media Release: 11 Nov 2002. Available from URL: http://www.adolor.com
Adolor Corporation. Adolor Announces Top-Line Results of Alvimopan Phase 3 Clinical Study. Media Release: 2 Apr 2003. Available from: URL: http://www.adolor.com
Adolor Corporation. Adolor Corporation Announces Positive Top-Line Results in 2nd Phase 3 Study of Alvimopan in Postoperative Ileus. Media Release: 23 Sep 2003. Available from URL: http://www.adolor.com
Adolor Corporation, GlaxoSmithKline. Data Published from Entereg(TM) (alvimopan) Phase 3 Clinical Trial in Annals of Surgery. Media Release: 23 Sep 2004. Available from URL: http://www.adolor.com
Zimmerman DM, Gidda JS, Cantrell BE. Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxy-phenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders. Journal of Medicinal Chemistry 37: 2262–2265, 22 Jul 1994
Liu SS, Hodgson PS, Carpenter RL, et al. ADL 8-2698, a trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesia. Clinical Pharmacology and Therapeutics 69: 66–71, Jan 2001
Adolor Corporation. Adolor Corporation successfully completes two phase 2 clinical trials of ADL 8-2698 in opioid induced bowel dysfunction — plans to begin phase 3 clinical trials. Media Release [3 pages], 18 Jan 2001. Available from URL: http://www.adolor.com
GlaxoSmithKline, Adolor Corporation. GlaxoSmithKline and Adolor Present Positive Results From a Clinical Study of alvimopan (Entereg(R)). Media Release: 4 May 2006. Available from URL: http://www.gsk.com
LY 246736 speeds postoperative recovery of intestinal function. Inpharma 1308: 8, 6 Oct 2001
Rights and permissions
About this article
Cite this article
Alvimopan. Drugs in R D 7, 245–253 (2006). https://doi.org/10.2165/00126839-200607040-00004
Published:
Issue Date:
DOI: https://doi.org/10.2165/00126839-200607040-00004