Drugs in R & D

, Volume 7, Issue 4, pp 203–217 | Cite as

The Potential of Plant Virus Vectors for Vaccine Production

  • Vidadi Yusibov
  • Shailaja Rabindran
  • Ulrich Commandeur
  • Richard M. Twyman
  • Rainer Fischer
Review Article

Abstract

Plants viruses are versatile vectors that allow the rapid and convenient production of recombinant proteins in plants. Compared with production systems based on transgenic plants, viral vectors are easier to manipulate and recombinant proteins can be produced more quickly and in greater yields. Over the last few years, there has been much interest in the development of plant viruses as vectors for the production of vaccines, either as whole polypeptides or epitopes displayed on the surface of chimeric viral particles. Several viruses have been extensively developed for vaccine production, including tobacco mosaic virus, potato virus X and cowpea mosaic virus. Vaccine candidates have been produced against a range of human and animal diseases, and in many cases have shown immunogenic activity and protection in the face of disease challenge. In this review, we discuss the advantages of plant virus vectors, the development of different viruses as vector systems, and the immunological experiments that have demonstrated the principle of plant virus-derived vaccines.

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Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  • Vidadi Yusibov
    • 1
  • Shailaja Rabindran
    • 1
  • Ulrich Commandeur
    • 2
  • Richard M. Twyman
    • 3
  • Rainer Fischer
    • 2
    • 4
  1. 1.Fraunhofer USA Center for Molecular BiotechnologyNewarkUSA
  2. 2.Institute for Molecular Biotechnology, Biology VIIRWTH AachenAachenGermany
  3. 3.Department of BiologyUniversity of YorkHeslington, YorkUK
  4. 4.Fraunhofer Institute for Molecular Biology and Applied Ecology (IME)AachenGermany

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