Skip to main content
Log in

Decitabine

2′-Deoxy-5-azacytidine, Aza dC, DAC, Dezocitidine, NSC 127716

  • Adis R&D Profile
  • Published:
Drugs in R & D Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Table I
Table II

Notes

  1. This profile has been selected from R&D Insight™, a pharmaceutical intelligence database produced by Adis International Ltd.

References

  1. SuperGen Inc. SuperGen’s Decitabine Granted ‘Orphan Drug’ Status in Europe. Media Release: 28 Feb 2003. Available from: URL http://www.supergen.com

    Google Scholar 

  2. SuperGen Inc. SuperGen Completes Patient Enrollment in Investigational Phase III Clinical Study of Decitabine. Media Release: 17 Mar 2003. Available from: URL: http://www.supergen.com

    Google Scholar 

  3. Momparler RL, Bouffard DY, Momparler LF. Pilot phase I-II study on 5-aza-2′-deocycytidine (decitabine) in patients with metastatic lung cancer. Anti-Cancer Drugs 8: 358–368, Apr 1997

    Article  PubMed  CAS  Google Scholar 

  4. Petti MC, Mandelli F, Zagonel V, et al. Pilot study of 5-aza-2′-deoxycytidine (Decitabine) in the treatment of poor prognosis acute myelogenous leukemia patients: Preliminary results. Leukemia 7 (Suppl. 1): 36–41, May 1993

    PubMed  Google Scholar 

  5. Kantarjian H, O’Brien S, Beran M. Results with decitabine, a hypomethylating agent, in the treatment of chronic myelogenous leukemia in accelerated or blastic phases. Blood 88 (Suppl. 1): 199, Part 2, 15 Nov 1996

    Google Scholar 

  6. Pinto A, Milan I, Concetta Petti. Decitabine in acute myeloid leukemia and myelodysplastic syndromes. 40th Annual Meeting American Society of Hematology: 6–9, 4 Dec 1998

    Google Scholar 

  7. Kantarjian HM, O’Brien SM, Keating M, et al. Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia. Leukemia 11: 1617–1620, Oct 1997

    Article  PubMed  CAS  Google Scholar 

  8. Willemze R, Suciu S, Archimbaud E, et al. A randomized phase II study on the effects of 5-Aza-2′-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893). Leukemia 11 (Suppl. 1): 24–27, Mar 1997

    Google Scholar 

  9. Wijermans P, Lübbert M, Verhoef G, et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. Journal of Clinical Oncology 18: 956–962, Mar 2000

    PubMed  CAS  Google Scholar 

  10. Lenzi R, Raber MN, Gravel D, et al. Phase I and II trials of a laboratory-derived synergistic combination of cisplatin and 2′-deoxy-5-azacytidine. International Journal of Oncology 6: 447–450, Feb 1995

    PubMed  CAS  Google Scholar 

  11. Vermorken JB, Tumolo S, Roozendaal KJ. 5-aza-2′-deoxycytidine in advanced or recurrent cancer of the uterine cervix. European Journal of Cancer 27: 216–217, No. 2, 1991

    Article  PubMed  CAS  Google Scholar 

  12. Daskalakis M, Nguyen TT, Nguyen C, et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood 100: 2957–2964, 15 Oct 2002

    Article  PubMed  CAS  Google Scholar 

  13. Richel DJ, Colly LP, Kluin-Nelemans JC. The antileukaemic activity of 5-aza-2 deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia. British Journal of Cancer 64: 144–148, Jul 1991

    Article  PubMed  CAS  Google Scholar 

  14. Willemze R, Archimbaud E, Muus P. Preliminary results with 5-aza-2′-deoxycytidine (DAC)- containing chemotherapy in patients with relapsed or refractory acute leukemia. Leukemia 7 (Suppl. 1): 49–50, May 1993

    PubMed  Google Scholar 

  15. Sacchi S, Kantarjian HM. Decitabine is effective for the treatment of chronic myelogenous leukemia in non-lymphoid blastic phase. 40th Annual Meeting American Society of Hematology: 12–14, 4 Dec 1998

    Google Scholar 

  16. Giralt S, Cohen A, Davis M. Phase I/II study of decitabine with allogeneic peripheral blood stem cell transplantation for treatment of relapse after allogeneic progenitor cell transplantation. 40th Annual Meeting American Society of Hematology: 15–16, 4 Dec 1998

    Google Scholar 

  17. Ravandi F, Kantarjian H, Cohen A, et al. Decitabine with allogeneic peripheral blood stem cell transplantation in the therapy of leukemia relapse following a prior transplant: results of a phase I study. Bone Marrow Transplantation 27: 1221–1225, No. 12, Jun 2001

    Article  PubMed  CAS  Google Scholar 

  18. Sacchi S, Kantarjian HM, O’Brien S, et al. Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients. Cancer 86: 2632–2641, 15 Dec 1999

    Article  PubMed  CAS  Google Scholar 

  19. SuperGen Inc. Supergen’s Decitabine Active as Part of Combination Preparative Regimen for Allergenic Blood and Bone Marrow Transplants. Media Release: 31 Mar 2003. Available from: URL: http://www.supergen.com

    Google Scholar 

  20. SuperGen Inc. Studies Suggest SuperGen’s Decitabine is Effective in Elderly Patients with High-Risk Myelodysplastic Syndrome (MDS). Media Release: 6 Dec 2002. Available from: URL: http://www.supergen.com

    Google Scholar 

  21. Koshy M, Dorn L, Bressler L, et al. 2-Deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia. Blood 96: 2379–2384, 1 Oct 2000

    PubMed  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Decitabine. Drugs R&D 4, 179–184 (2003). https://doi.org/10.2165/00126839-200304030-00007

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00126839-200304030-00007

Keywords

Navigation