This is a preview of subscription content, log in via an institution to check access.
References
Wang X, Rondu F, Lamouri A, et al. Effect of S-21663 (PMS 812), an imidazoline derivative, on glucose tolerance and insulin secretion in a rat model of type II diabetes. J Pharmacol Exper Ther 1996 Jul; 278: 82–9
Rondu F, Le Bihan G, Wang X, et al. Structure-activity relationships in a series of substituted piperazines potentially active in non-insulin-dependent diabetes mellitus [abstract]. XIIIth International Symposium of Medicinal Chemistry. 1994 Sep 19–23; Paris, 263
Le Brigand L, Virsolvy A, Peyrollier K, et al. Stimulation of insulin release fromthe MIN6 cell line by a newimidazoline compound, S-21663: evidence for the existence of a novel imidazoline site in beta cells. Br J Pharmacol 1997 Oct; 122: 786–91
Le Bihan G, Rondu F, Pelé-Tounian A, et al. Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 2. Syntheses and biological activities of 1,4-dialkyl-, 1,4-dibenzyl, and 1-benzyl- 4-alkyl-2-(4′,5′-dihydro-1′H-imidazol-2′-yl)piperazines and isosteric analogues of imidazoline. J Med Chem 1999 May 6; 42: 1587–603
Rights and permissions
About this article
Cite this article
PMS 812. Drugs R&D 2, 116–117 (1999). https://doi.org/10.2165/00126839-199902020-00009
Published:
Issue Date:
DOI: https://doi.org/10.2165/00126839-199902020-00009