Skip to main content
SpringerLink
Log in

TAK 044

  • Adis R&D Profile
  • Published:
Drugs in R & D Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Ohnishi M, Wada A, Tsutamoto T, et al. Comparison of the acute effects of a selective endothelin ET(A) and a mixed ET(A)/ET(B) receptor antagonist in heart failure. Cardiovasc Res 1998 Sep; 39: 617–24

    Article  PubMed  CAS  Google Scholar 

  2. Maruya J, Norota I, Endoh M. Effects of TAK-044, a nonselective antagonist of the ET(A) and ET(B) receptor, on the positive inotropic effect induced by endothelin-1 and endothelin-3 in rabbit papillary muscle. Jpn J Pharmacol 1997; 73 Suppl. I: 236

    Google Scholar 

  3. Ikeda S, Awane Y, Kusumoto K, et al. Anewendothelin receptor antagonist, TAK-044, shows long-lasting inhibition of both ET(A)- and ET(B)-mediated blood pressure responses in rats. J Pharmacol Exp Ther 1994 Aug; 270 (2): 728–33

    PubMed  CAS  Google Scholar 

  4. Webb DJ, Ferro CJ, Haynes WG, et al. Vasodilator effects of the ET(A/B) receptor antagonist, TAK-044, in humans. Br J Clin Pharmacol 1995 Nov; 40: 503P

    Google Scholar 

  5. Sütsch G, Fleisch M, Yan X-W, et al. Acute hemodynamic and renal effects of the endothelin-1 receptor antagonist TAK-044 in patients without heart failure. J Am Coll Cardiol 1997 Feb; 29 Suppl. A: 444

    Google Scholar 

  6. Watanabe T, Kusumoto K, Awane Y, et al. Pharmacological profile of an endothelin receptor antagonist TAK-044, and its effects in animal models of acute myocardial infarction and acute renal failure. Can J Physiol Pharmacol 1994; 72 Suppl. 1: 102

    Google Scholar 

  7. Watanabe T, Awane Y, Ikeda S, et al. Pharmacology of a nonselective ET(A) and ET(B) receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br J Pharmacol 1995 Mar; 114: 949–54

    Article  PubMed  CAS  Google Scholar 

  8. Watanabe T, Fujino M. TAK-044: an endothelin receptor antagonist. Cardiovasc Drug Rev 1996; 14 No. 1: 36–46

    Article  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

TAK 044. Drugs R&D 2, 35–37 (1999). https://doi.org/10.2165/00126839-199902010-00010

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00126839-199902010-00010

Keywords

Search

Navigation