Skip to main content
Log in

Bosentan

RO 470203

  • Adis R&D Profile
  • Published:
Drugs in R & D Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Weber C, Schmitt R, Birnboeck H, et al. Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects. Clin Pharmacol Ther 1996 Aug; 60: 124–37

    Article  PubMed  CAS  Google Scholar 

  2. Sütsch G, Hunziker P, Kim JH, et al. Maintained efficacy of prolonged endothelin-antagonist therapy with bosentan in severe chronic heart failure: a preliminary study on tolerability and safety. 6th International Congress on Cardiovascular Pharmacotherapy. 1996 Feb 26–29; Sydney, A36

    Google Scholar 

  3. Wenzel RR, Fleisch M, Schmitt R, et al. Effects of the endothelin antagonist bosentan on coronary and systemic haemodynamics in patients with coronary artery disease. J Hypertens Suppl 1998; 16 (2): 88

    Google Scholar 

  4. Sütsch G, Kiowski W, Yan X-W, et al. Short-term oral endothelinreceptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure. Circulation 1998 Nov 24; 98: 2262–8

    Article  PubMed  Google Scholar 

  5. Packer M, Caspi A, Charlon V, et al. Multicenter, double-blind, placebo-controlled study of long-term endothelin blockade with bosentan in chronic heart failure — results of the REACH-1 trial. Circulation 1998 Oct 27; 98 Suppl.: 3

    Google Scholar 

  6. Teerlink JR, Löffler B-M, Hess P, et al. Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure: acute effects of the endothelin receptor antagonist Ro 47–0203 (bosentan). Circulation 1994 Nov; 90: 2510–8

    Article  PubMed  CAS  Google Scholar 

  7. Shimoyama H, Sabbah HN, Borzak S, et al. Hemodynamic effects of intravenous bosentan (RO 47–0203) in dogs with chronic heart failure. 1st International Meeting of the Working Group on Heart Failure; 1995 Apr 1–4; Amsterdam, 50

    Google Scholar 

  8. Mulder P, Richard V, Hogie M, et al. Long-term effects of the endothelin antagonist bosentan in a rat model of heart failure. Arch Mal Coeur Vaiss 1997 Apr; 90: 569

    Google Scholar 

  9. Choussat R, Hittinger L, Barbe F, et al. Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs. Cardiovasc Res 1998 Sep; 39: 580–8

    Article  PubMed  CAS  Google Scholar 

  10. Kiowski W, Bertel O, Sütsch G, et al. Vasodilator effects of the endothelin-1 receptor antagonist bosentan in patients with severe chronic heart failure. J Am Coll Cardiol 1995 Feb; (Spec. Issue): 296

    Google Scholar 

  11. Kiowski W, Sütsch G, Hunziker P, et al. Evidence for endothelin- 1-mediated vasoconstriction in severe chronic heart failure. Lancet 1995 Sep 16; 346: 732–6

    Article  PubMed  CAS  Google Scholar 

  12. Sütsch G, Hunziker P, Kim JH, et al. The effect of prolonged endothelin-antagonist therapy with bosentan in severe chronic heart failure. Eur J Clin Invest 1996; 26 Suppl. 1: 51

    Google Scholar 

  13. Sütsch G, Hunziker P, Christen St, et al. Clinical, hormonal and haemodynamic effects of an orally active endothelin-1-receptor antagonist in patients with severe chronic heart failure [abstract]. Eur Heart J 1997; 18 Suppl.: 584

    Google Scholar 

  14. Richard V, Kaeffer N, Hogie M, et al. Role of endogenous endothelin in myocardial and coronary endothelial injury after ischaemia and reperfusion in rats: studies with bosentan, a mixed ETA-ETB antagonist. Br J Pharmacol 1994 Nov; 113: 869–76

    Article  PubMed  CAS  Google Scholar 

  15. Li X-S, Wang Q-D, Pernow J. Beneficial effects of the endothelin receptor antagonist bosentan on myocardial and endothelial injury following ischaemia/reperfusion in the rat. Eur J Pharmacol 1995 Sep 5; 283: 161–8

    Article  PubMed  CAS  Google Scholar 

  16. Wang Q-D, Li X-S, Lundberg JM, et al. Protective effects of non-peptide endothelin receptor antagonist bosentan onmyocardial ischaemic and reperfusion injury in the pig. Cardiovasc Res 1995 Jun; 29: 805–12

    PubMed  CAS  Google Scholar 

  17. Filep JG, Fournier A, Földes-Filep É. Effects of the ET(A)/ET(B) receptor antagonist, bosentan on endothelin-1-induced myocardial ischaemia and oedema in the rat. Br J Pharmacol 1995 Sep; 116: 1745–50

    Article  PubMed  CAS  Google Scholar 

  18. Zhang Y, Oliver JR, Horowitz JD. Endothelin B receptormediated vasoconstriction induced by endothelin A receptor antagonist. Cardiovasc Res 1998 Sep; 39: 665–73

    Article  PubMed  CAS  Google Scholar 

  19. Fraccarollo D, Galuppo P, Hu K, et al. Chronic endothelin receptor blockade attenuates progressive ventricular dilation and improves cardiac function in rats with myocardial infarction: possible involvement of myocardial endothelin system in ventricular remodeling. Circulation 1997 Dec 2; 96: 3963–73

    Article  PubMed  CAS  Google Scholar 

  20. Wenzel RR, Noll G, Fleisch M, et al. Effects of the endothelin antagonist bosentan after intravenous administration on coronary and systemic hemodynamics in patients with coronary artery disease. J Am Coll Cardiol 1997 Feb; 29 Suppl. A: 445

    Google Scholar 

  21. Wenzel RR, Fleisch M, Shaw S, et al. Hemodynamic and coronary effects of the endothelin antagonist bosentan in patients with coronary artery disease. Circulation 1998 Nov 24; 98: 2235–40

    Article  Google Scholar 

  22. Sütsch G, Bertel O, Rickenbacher P, et al. The effect of endothelin-receptor-antagonism on the activated angiotensin- aldosterone-system in patients with chronic congestive heart failure [abstract]. Eur Heart J 1998 Aug; 19 Suppl.: 354

    Google Scholar 

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bosentan. Drugs R&D 2, 19–23 (1999). https://doi.org/10.2165/00126839-199902010-00004

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00126839-199902010-00004

Keywords

Navigation