References
Lucien J, Dias VC, LeGatt DF, et al. Blood distribution and single-dose pharmacokinetics of leflunomide. Ther Drug Monit 1995; Oct 17: 454–9
Morris RE. New small molecule immunosuppressants for transplantation: review of essential concepts. J Heart Lung Transplant 1993 Nov-Dec; 12: S275–86
Furst DE. Cyclosporin, leflunomide and nitrogen mustard. Baillieres Clin Rheumatol 1995 Nov; 9: 711–29
Zivkovic M, Seifert H, Campion G, et al. Leflunomide is a safe and effective drug in the therapy of active rheumatoid arthritis. Br J Rheumatol 1994; 33 (Suppl. 1, Abstracts): 149
Rozman B, Domlian Z, Popovic M, et al. Long term administration of leflunomide to patients with rheumatoid arthritis. Arthritis Rheum 1994 Sep; 37 Suppl.: 339
Pilipovi N, Mladenovi V. Leflunomide in the treatment of patients with rheumatoid arthritis. Clin Exper Rheumatol 1995 Sep–Oct; 13 Suppl. 12: 49
Malkin MG, Mason WP, Lieberman FS, et al. Phase I study of SU101, a novel signal transduction inhibitor, in recurrent malignant glioma. 33rd Annual Meeting of the American Society of Clinical Oncology; 1997 May 17; 385
Malkin MG, Rosen L, Lopez AM, et al. Phase 2 study of SU101, a PDGF-R signal transduction inhibitor, in recurrent malignant glioma. 34th Annual Meeting of the American Society of Clinical Oncology; 1998 May 16; 17: 390
SUGEN Inc. SUGEN announces preliminary phase II prostate data on SU101; shows evidence of positive activity in hormone-refractory prostate cancer patients. Media Release: [2 pages], 1998 Nov 12
Brazelton TR, Morris RE. Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. Curr Opin Immunol 1996 Oct; 8: 710–20
Ulrichs K, Wang H, Müller-Ruchholtz W. Down-regulation of xenophile antibodies by 15-deoxyspergualin in an experimental animal model. Transplant Proc 1994 Apr; 26: 994–6
Swan SK, Crary GS, Guijarro C, et al. Immunosuppressive effects of leflunomide in experimental chronic vascular rejection. Transplantation 1995 Oct 27; 60: 887–90
D’Silva M, Candinas D, Achilleos O, et al. The immunomodulatory effect of leflunomide in rat cardiac allotransplantation. Transplantation 1995 Sep 15; 60: 430–7
Williams JW, Xiao F, Foster P, et al. Leflunomide in experimental transplantation: control of rejection and alloantibody production, reversal of acute rejection, and interaction with cyclosporine. Transplantation 1994 apr 27; 57: 1223–31
Xiao F, Chong A, Foster P, et al. Effect of leflunomide in control of acute rejection in hamster-to-rat cardiac xenografts. Transplant Proc 1995 Jun; 26: 1263–5
Bartlett RR, Anagnostopulos H, Zielinski T, et al. Effects of leflunomide on immune responses and models of inflammation. Springer Semin Immunopathol 1993 Apr; 14: 381–94
He G, McAlister VC, Lee TDG, et al. Oral leflunomide prevents small bowel allograft rejection in the rat. Transplant Proc 1994 Jun; 26: 1613
McChesney LP, Xiao F, Sankary HN, et al. An evaluation of leflunomide in the canine renal transplantation model. Transplantation 1994 Jun 27; 57: 1717–22
Yuh DD, Gandy KL, Morris RE, et al. Leflunomide prolongs pulmonary allograft and xenograft survival. J Heart Lung Transplant 1995 Nov–Dec; 14 Pt 1: 1136–44
Schorlemmer HU, Seiler FR, Bartlett RR. Prolongation of allogeneic transplanted skin grafts and induction of tolerance by leflunomide, a new immunosuppressive isoxazol derivative. Transplant Proc 1993 Feb; 25 Pt 1: 763–7
Wright Jr JR, Kearns H, McDonald AS. Leflunomide and cyclosporin-A prolong fish-to-mouse islet xenograft survival in BALB/C mice. Transplant Proc 1994 Jun; 26: 1310
Guo Z, Chong ASF, Shen J, et al. Prolongation of rat islet allograft survival by the immunosuppressive agent leflunomide. Transplantation 1997 Mar 15; 63: 711–6
Guo Z, Chong ASF, Tian Y, et al. Effect of leflunomide and cyclosporine on concordant xenogeneic islet transplantation in streptozotocin-induced and autoimmune diabetic mice. Transplant Proc 1997 Jun; 29: 2155
Wennberg L, Groth CG, Tibell A, et al. Triple drug treatment with cyclosporine, leflunomide and mycophenolate mofetil prevents rejection of pig islets transplanted into rats and primates. Transplant Proc 1997 Aug; 29: 2498
Wennberg L, Karlsson-Parra A, Sundberg B, et al. Efficacy of immunosuppressive drugs in islet xenotransplantation: leflunomide in combination with cyclosporine and mycophenolate mofetil prevents islet xenograft rejection in the pig-to-rat model. Transplantation 1997 May 15; 63: 1234–42
Rights and permissions
About this article
Cite this article
Leflunomide. Drugs R&D 1, 87–91 (1999). https://doi.org/10.2165/00126839-199901010-00029
Published:
Issue Date:
DOI: https://doi.org/10.2165/00126839-199901010-00029