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Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Therapeutics

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Abstract

There is compelling genetic and pharmacologic evidence to indicate that melanin-concentrating hormone receptor-1 (MCHR1) signaling is involved in the regulation of food intake and energy expenditure. The medical need for novel therapies to treat obesity and related metabolic disorders has led to a great deal of interest by pharmaceutical companies in the discovery of MCHR1 antagonists. Recent publications describing preclinical studies have demonstrated that small-molecule MCHR1 antagonists decrease food intake, bodyweight, and adiposity in rodent models of obesity. Results from ongoing early-stage clinical trials with MCHR1 antagonists are eagerly awaited, as is the movement of other MCHR1 antagonists into the clinic.

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Acknowledgments

The authors are employees of Schering-Plough Research Institute, the research and development arm of Schering-Plough Corporation.

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Authors and Affiliations

  1. Department of CV/Metabolic Diseases, Schering-Plough Research Institute, Kenilworth, New Jersey, USA

    Timothy J. Kowalski

  2. Medicinal Chemistry, Schering-Plough Research Institute, Kenilworth, New Jersey, USA

    Thavalakulamgar Sasikumar

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  1. Timothy J. Kowalski
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  2. Thavalakulamgar Sasikumar
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Correspondence to Timothy J. Kowalski.

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Kowalski, T.J., Sasikumar, T. Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Therapeutics. BioDrugs 21, 311–321 (2007). https://doi.org/10.2165/00063030-200721050-00003

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